耳后注射甲泼尼龙治疗特发性耳聋的疗效及对患者血液流变学和血浆Hcy水平的影响

Efficacy of post auricular injection of methylprednisolone on treatment of idiopathic deafness and its effect on hemorheology and plasma Hcy

目的探讨耳后注射甲泼尼龙治疗特发性耳聋患者的临床疗效及对血液流变学、血浆同型半胱氨酸(Hcy)水平的影响。方法将郑州中心医院2016年2月—2017年2月间收治的106例特发性耳聋患者按随机数字法分为2组,每组53例。对照组给予地塞米松,观察组在对照组基础上加用耳后注射甲泼尼龙。治疗后,比较2组患者纯音听阈值、血液流变学(血浆粘度、血细胞比容、血小板聚集率)、血浆Hcy水平及临床疗效。结果治疗前,2组纯音听阈值差异无统计学意义(P>0.05);治疗后,2组纯音听阈值均显著降低(P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组血浆粘度、血细胞比容、血小板聚集率差异无统计学意义(均P>0.05);治疗后,2组血浆粘度、血细胞比容、血小板聚集率均明显降低(均P<0.05),且观察组低于对照组(P<0.05)。治疗前,2组Hcy水平差异无统计学意义(P>0.05);治疗后,2组Hcy水平明显降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,观察组总有效率为96.23%,显著高于对照组的81.13%(P<0.05)。结论耳后注射甲泼尼龙治疗特发性耳聋疗效显著,可明显改善患者的血液流变学和血浆Hcy水平,值得临床推荐。

Objective To investigate the clinical efficacy of post auricular injection of methylprednisolone on treatment of idiopathic deafness and its effects on hemorheology and plasma Hcy. Methods A total of 106 patients with idiopathic deafness in our hospital from February, 2016 to February, 2017 were randomly divided into two groups according to random number method, 53 cases in every group. The control group was given dexamethasone, and observation group was added post auricular injection of methylprednisolone based on control group. After treatment, the pure tone threshold, hemorheology（plasma viscosity, hematocrit, platelet aggregation rate）, plasma Hey level, clinical efficacy of two groups were compared. Results Before treatment, there was no significant difference on pure tone threshold between the two groups （P 〉 0.05 ）. After treatment, the pure tone threshold of two groups were significantly decreased（ P 〈 0.05 ）, and pure tone threshold of observation group was lower than that of control group（ P 〈 0.05 ）. Before treatment, there was no significant difference on plasma viscosity, hematoerit, platelet aggregation rate between the two groups（P 〉0.05）. After treatment, the plasma viscosity, hematocrit, platelet aggregation rate of two groups were significantly decreased （P 〈 O. 05 ） , and plasma viscosity, hematocrit, platelet aggregation rate of observation group were lower than those of control group （P 〈 0.05 ）. Before treatment, there was no significant difference on Hey level between the two groups （P 〉 0.05 ）. After treatment, the Hey level of two groups were significantly decreased（ P 〈 0.05 ） , and Hcy level of observation group were lower than that of control group（P 〈 O. 05）. The total effective rate of observation group was 96.23% , which was significantly higher than that of control group（ 81.13% ） , P 〈 0.05. Conclusion The post auricular injection of methyl- prednisolone on treatment of idiopathic deafness could improve the hemorheology and plasma Hcy level of the patients, is very worth for clinical recommendation.