1166例成年男性肥胖与血清睾酮水平的关系

Relationship between obesity and serum testosterone level in 1166 adult males

目的探讨社区成年男性肥胖与血清睾酮水平的关系。方法以社区为单位分层整群抽取遵义市20岁及以上男性居民共1 166例行问卷调查和体格检查,空腹抽取肘静脉血检测血清总睾酮(TT)、性激素结合球蛋白(SHBG)和黄体生成素(LH),计算游离睾酮(cFT)、游离睾酮指数(FTI)和睾酮分泌指数(TSI)。结果 1 166例成年男性血清TT、SHBG、cFT、FTI、TSI、LH水平分别为(16.83±4.90)nmol/L、(42.15±20.21)nmol/L、(0.31±0.10)nmol/L、0.46±0.19、3.40±2.04、(6.77±5.14)IU/L。Pearson相关分析显示腰围身高比(WHtR)、体质量指数(BMI)、腰围(WC)分别与TT、SHBG、TSI和LH呈负相关,与FTI呈正相关;WHtR与cFT呈负相关,BMI和WC与LH呈负相关,差异均有统计学意义(P<0.05)。多元线性回归分析显示WHtR与TT、SHBG、TSI、LH均呈负相关;与FTI呈正相关,差异均有统计学意义(P<0.01)。结论成年男性向心性肥胖可能与血清TT、SHBG、TSI、LH下降及FTI上升有关。

Objective To explore the relationship between obesity and serum testosterone level among community adult males. Methods The stratified cluster sampling method was adopted to extract 1 166 male residents aged 20 years old and over in Zunyi City and conduct the questionnaire survey and physical examination. Fasting venous blood samples were collected for detec- ting the serum total testosterone（TT）, sex hormone binding globulin（SHBG） and luteinizing hormone（LH）. Then free testosterone index（cFT） ,free testosterone index（FTI） and testosterone secreting index（TSI） were calculated. Results The average levels of se- rum TT,SHBG,cFT,FTI,TSI and LH in 1 166 adult males were（16.83±4.90）nmol/L, （42.15± 20.21）nmol/L, （0.31±0.10） nmol/L, （0.46±0.19）IU/L, （3.40±2.04）IU/L and（6.77~5.14）IU/L respectively ~ the Pearson correlation analysis showed that WHtR, BMI and WC were negatively correlated with TT, SHBG,TSI and LH ,and were positively correlated with FTI, WHtR was negatively correlated with cFT,BMI and WC were negatively correlated with LH,the differences were statistically significant（P〈0.05）. The multivariate linear regression analysis shown that WHtR was negatively correlated with TT, SHBG, TSI and LHand was positively correlated with FTI,the differences were statistically significant（P〈0.01）. Conclusion Adult male central obesity may be associated with the decrease of serum TT,SHBG,TSI and LH levels,and increase of FTI level.