耐碳青霉烯类肠杆菌科细菌主动筛查研究进展

Research progress on active screening of carbapenem-resistant Enterobacteriaceae

耐碳青霉烯类抗菌药物的肠杆菌科细菌的感染受到国内外广泛关注,是当前最受关注的耐药威胁之一。如何更好地预防和控制耐碳青霉烯类抗菌药物的肠杆菌科细菌是全球研究的热点和难点问题。越来越多的研究把主动筛查作为防控耐碳青霉烯类抗菌药物的肠杆菌科细菌的一项干预措施。本文从定植与感染的关系、筛查的效果评价、主动筛查人群、筛查采样方法、筛查频率及主动筛查有待进一步研究的领域等方面进行综述,旨在为耐碳青霉烯类抗菌药物的肠杆菌科细菌的防控提供参考。

The infection of carbapenem-resistant Enterobacteriaceae（CRE） has attracted wide attention at home and abroad and is one of the resistance threats that be mostly concerned. It is a hot and difficult global issue to study on the better prevention and control of the CRE. The active screening has been used as an intervention to the preven- tion and control of the CRE strains in more and more studies. The correlation between colonization and infection, effect of screening, population of active screening, screening and sampling methods, frequency of screening and active screening, which needed to be further studied, were reviewed so as to provide guidance for prevention and control of the CRE strains.