糖尿病肾病维持性血液透析患者骨密度的测定结果分析

Analysis of the measurement results of bone mineral density in maintenance hemodialysis patients with diabetic nephropathy

目的对糖尿病肾病(diabetic nephropathy,DN)维持性血液透析(maintenance hemodialysis,MHD)患者骨质疏松症(osteoporosis,OP)患病情况进行测定分析,探讨DN维持性血液透析患者OP情况。方法选择MHD患者63例,其中DN 28例,非DN 35例,采用双能X线骨密度仪测定骨密度(bone mineral density,BMD),同时收集患者一般资料和血清指标,了解OP的患病情况。用SPSS17.0软件进行统计学分析。结果 DN组OP总患病率为60.71%,高于非DN组(25.71%),骨折发生率增高,BMD降低,差异有统计学意义(P<0.05)。结论 DN维持性血液透析患者较非DN维持性血液透析患者骨密度更低,OP患病率及骨折发生率更高,应定期检测并给予针对性治疗。

Objective To investigate the prevalence of osteoporosis（OP） in diabetic nephropathy（DN） patients with maintenance hemodialysis（MHD） by measuring and analyzing the prevalence of osteoporosis（OP） in diabetic nephropathy （DN） patients with maintenance hemodialysis（MHD）. Methods 63 patients with MHD were selected, including 28 cases of DN and 35 cases of non-DN. The bone mineral density（BMD） was measured by dual-energy X-ray absorptiometry. The general data and serum indexes were collected to understand the prevalence of OP. Statistical analysis was performed using SPSS17.0 software. Results The total morbidity rate of OP in DN group was 60.71%, higher than that in non-DN group（25.71%）. The incidence of fractures increased and BMD decreased in DN group. The difference was statistically significant（P〈0.05）. Conclusion Patients with DN hemodialysis have lower bone mineral density, higher morbidity rate of OP and higher incidence of fractures than non-DN hematologic patients. And the patients with DN hemodialysis should be regularly tested and given targeted therapy.