丁苯酞治疗急性脑缺血引起肢体活动障碍的临床观察

Clinical observation of butylphthalide in the treatment of limb activity disorder induced by acute cerebral ischemia

目的探讨丁苯酞治疗急性脑缺血引起肢体活动障碍的临床疗效。方法将我院98例急性脑缺血患者随机分为两组。对照组49例给予内科常规治疗,而试验组49例在对照组基础上加用丁苯酞。比较两组临床疗效、NIHSS评分、Barthel评分及生活质量评分。结果试验组患者治愈率、总有效率分别为55.1%、95.9%,高于对照组32.7%、79.6%(P<0.05);治疗4周后试验组NIHSS评分明显降低,并较同期对照组低(P<0.05);治疗4周后试验组Barthel评分升高,较同期对照组高(P<0.05);治疗4周后试验组生活质量评分提高,并明显较同期对照组升高;试验组不良反应发生率4.1%与对照组10.2%比较,差异无统计学意义(P>0.05)。结论丁苯酞治疗急性脑缺血效果佳,其临床有效率高,可提高肢体功能,改善生活质量,不良反应少,值得临床选择。

Objective To explore the clinical efficacy of butyphthalide in the treatment of limb activity disorder caused by acute cerebral ischemia. Methods 98 patients with acute cerebral ischemia in our hospital were randomly divided into two groups. 49 patients in the control group were given routine medical treatment, while 49 patients in the experimental group were further given butylphthalide on the basis of the control group. The differences in clinical efficacy, NIHSS score, Barthel score and quality of life score were compared between the two groups. Results The cure rate and total effective rate were 55.1% and 95.9% in the experimental group, which were higher than those of 32.7% and 79.6%, respectively in the control group, and the differences were statistically significant（P〈0.05）; the NIHSS score in the experimental group was decreased 4 weeks after treatment, which was also lower than that in the control group during the same period, and the difference was statistically significant（P〈0.05）; the Barthel score in the experimental group was increased 4 weeks after treatment, which was also higher than that in the control group during the same period, and the difference was statistically significant（P〈0.05）; the quality of life score in the experimental group 4 weeks after the treatment was significantly increased, which was also higher than that in the control group during the same period, and the difference was statistically signifieant（P〈0.05）; the incidence rate of adverse reactions in the experimental group was 4.1%, slightly lower than that in the control group（10.2%）, and the difference was not significant（P〉0.05）, Conclusion The effect of butylphthalide in the treatment of acute cerebral ischemia is favorable. Its clinical efficiency is high, limb function is improved, the quality of life is also improved greatly, with less adverse reactions, which is worthy of clinical application.