莫西沙星与抗结核药物联用治疗难治性结核性脑膜炎的疗效观察

Observation on the efficacy of moxifloxacin in combination with antituberculosis drugs in the treatment of refractory tuberculous meningitis

目的探讨莫西沙星与抗结核药物联用治疗难治性结核性脑膜炎的疗效。方法选取2016年5月~2017年4月在本院进行难治性结核性脑膜炎的患者142例作为研究对象,根据治疗方式的不同分为对照组和观察组,各71例。对照组采用传统的抗结核药物进行治疗,观察组采用莫西沙星与抗结核药物联用的方式来治疗难治性结核性脑膜炎。对比分析两组疗效及满意度。结果治疗后,观察组脑脊液的检查结果:葡萄糖(2.83±0.61)mmol/L、氯化物(123.32±3.29)mmol/L、蛋白质(0.37±0.07)g/L、白细胞数(7.85±2.11)×106/L、压力(140.11±10.44)mm H2O明显优于对照组,差异有统计学意义(P<0.05);对照组患者的总满意率为90.14%,观察组患者的总满意率为98.59%,对照组的患者满意度明显低于观察组,差异有统计学意义(P<0.05)。结论莫西沙星与抗结核药物联用治疗难治性结核性脑膜炎的方式在临床治疗上相比于传统拮抗药物治疗的方式有明显优势,能够有效改善患者的病情,提高患者满意度。

Objective To investigate and observe the efficacy of moxifloxacin in combination with antituberculosis drugs in the treatment of refractory tuberculous meningitis. Methods 142 patients with refractory tuberculous meningitis who were treated in our hospital from May 2016 to April 2017 were selected as the study subjects. According to the dif- ferent treatment methods, the patients were divided into the control group and the observation group, with 71 patients in each group. The control group was given traditional anti-TB drugs for treatment, and the observation group was given moxifloxacin in combination with anti-TB drugs to treat refractory tuberculous meningitis. The efficacy and satisfaction were compared and analyzed between the two groups. Results The test results of cerebrospinal fluid after treatment in the observation group： Glucose （2.83±0.61）mmol/L, chloride （123.32±3.29）mmol/L, protein （0.37±0.07）g/L, white blood cell count （7.85±2.11） × 106/L and pressure （140.11 ± 10.44）mmH2O were significantly better than those in the control group, and the differenees were statistically significant （P〈0.05）; the total satisfaction rate in the patients in the control group was 90.14%, and the total satisfaction rate in the patients in the observation group was 98.59%. The satisfaction of patients in the control group was significantly lower than that in the observation group, and the difference was statis- tically significant （P〈0.05）. Conclusion Moxifloxaein in eombination with antitubereulosis drugs in the treatment of re- fraetory tuberculous meningitis has obvious advantages in the clinical treatment eompared with the traditional antago- nistic drug, whieh can effeetively improve the patient＇s condition and improve patient＇s satisfaction.