自拟中药颗粒与桂枝茯苓胶囊治疗子宫肌瘤临床疗效对比分析

Self-made TCM granule versus Guizhi Fuling Capsule in treatment of hysteromyoma

目的探讨自拟中药颗粒与桂枝茯苓胶囊治疗子宫肌瘤的临床效果。方法选取2014年7月至2016年9月本院收治的子宫肌瘤患者438例作为研究对象，随机将438例患者分为对照组及观察组，各219例。观察组应用自拟中药颗粒进行治疗，对照组口服桂枝茯苓胶囊进行治疗。疗程结束后统计比较两组总有效率。结果观察组临床疗效总有效率高于对照组（97．26％比63．93％），差异具有统计学意义（P〈0．05）。两组治疗后子宫以及肌瘤体积均较治疗前明显缩小（均P〈0．05）；观察组治疗后子宫以及肌瘤体积较对照组缩小更明显（均P〈0．05）。两组治疗后孕酮和雌二醇浓度均较治疗前明显下降（均P〈0．05）；且观察组孕酮和雌二醇浓度下降幅度大于对照组（均P〈0．05）。观察组与对照组不良反应发生率比较，差异有统计学意义（x2=6．845，P=0．006）。结论自拟中药颗粒治疗子宫肌瘤临床效果显著，治疗后患者子宫以及肌瘤体积明显缩小，临床症状及体征明显改善，且不良反应少，值得临床推广运用。

Objective To investigate the curative effects of self-made TCM granule and Guizhi Fuling Capsule in the treatment of hysteromyoma. Methods 438 patients with hysteromyoma treated at our hospital from July, 2014 to September, 2016 were selected as the research objects and were randomly divided into a control group and an observation group, 219 cases for each group. The observation group were treated with self-made TCM granule and the control group with Guizhi Fuling Capsule. At the end of the treatment, the total effective rate of the two groups was compared. Results The total effective rate was higher in the observation group than in the control group （97.26% vs. 63.93%）, with a statistical difference （P 〈 0.05）. After the treatment, the uterine and fibroid volumes were significantly reduced in the two groups （P 〈 0.05）. After the treatment, the uterine and fibroid volumes in the observation group were significantly lower than those in the control group （P 〈 0.05）. After the treatment, the progesterone and estradiol concentrations were significantly lower than those before the treatment in the two groups （P 〈 0.05）. The progesterone and estradiol concentrations in the observation group were lower than those in the control group after the treatment （P 〈 0.05）. The incidence of adverse reactions was lower in the observation group than in the control group （X 2=6.845, P=0.006）. Conclusions The curative effect of self-made TCM granule in the treatment of hysteromyoma is obvious. After the treatment, the volume of uterus and myoma was obviously reduced, the clinical symptoms and signs were obviously improved, and the side effects were few. Therefore, it is worth being clinically generalized.