基于复杂网络的真武汤治疗糖尿病肾病的靶点作用研究

Target Research of Zhenwu Decoction Based on Complex Systems

目的：从复杂系统角度对真武汤治疗糖尿病肾病的作用机制进行研究。方法：以“茯苓”、“白术”、“芍药”、“附子”、“生姜”为关键词检索中国中药化学成分数据库、Drugbank数据库和《中华人民共和国药典》（2010版）获取中药、成分、靶点信息,并建立数据集,以Cytoscape软件为载体,构建中药-成分-靶点之间的复杂网络模型,并推测出药物组方与作用靶点之间的关系。结果：中药-成分-靶点网络是一个多途径、多环节的小世界网络,部分节点度相对较低,且各药物的重复靶点较少,表明该网络具有无标度属性;聚类结果表明,各味中药中至少含有一种有效成分与靶点存在作用关系。结论：真武汤在糖尿病肾病的治疗中存在能够作用于相关靶点的有效成分。

Objective ： To study the mechanism of Zhenwu Decoction in the treatment of diabetic nephropathy from the perspective of complex systems. Methods ： Put Tuckahoe, Atractylodes, Penoy, Monkshood and Ginger were as the key- words to search the chemical constituents of Traditional Chinese Medicine database, Drugbank database and China Phar- macopoeia （2010 Edition） to get the information of Chinese medicine, composition and target information, and then we established a data set. With the help of Cytoscape software, we set up a construction of complex network model about Chinese medicine - ingredients - target, and inferred the relationship between prescription and drug targets. Results： Chinese medicine - ingredients - target network is a small world network with multi - way and multi - link. Part of the node degree is relatively low, and the repeat target of the drug is less, indicating that the network has scale - free proper- ties. Clustering results show that all the traditional Chinese medicines containing at least one active ingredient and target. Conclusion：The effective ingredients of Zhenwu Decoction in treating diabetic nephropathy can act on related targets.