脂质代谢相关microRNA概述

Overview of lipid metabolism related microRNA

microRNA是基因表达过程的重要调控因子,其在细胞分化、增殖、凋亡及脂质代谢等多个方面都发挥着非常重要的作用,microRNA对脂质代谢的调节一直是近些年生物医学的研究热点。脂质代谢相关microRNA主要包括microRNA-33、microRNA-122、microRNA-370、microRNA-758、microRNA-27、microRNA-30c、microRNA-223、microRNA-144等,特别是microRNA-122和microRNA-33在调节体内胆固醇和脂肪酸平衡方面起主要作用。microRNA影响着细胞分化及脂质代谢等多种生物过程,其自身也受到转录因子、脂肪细胞因子和环境因素等的反馈调控,不同microRNA通过对mRNA的作用组成了复杂的调控网络。本文就microRNA调控脂质代谢的作用及方式进行综述。

MicroRNA is an important regulatory factor in the process of gene expression, which plays a very important role in cell differentiation, proliferation, apoptosis and lipid metabolism. Research on microRNA and lipid metabolism has been a hotspot in recent years. The microRNA-33, microRNA-122, microRNA-370, microRNA-758, microRNA-27, microRNA-30c, microRNA-223 and microRNA-144 were mainly involved in the microRNAs related to lipid metabolism. Among them, microRNA-122 and microRNA-33 play a major role in regulating cholesterol and fatty acid balance in vivo. MicroRNAs are involved in the regulation of cell differentiation and lipid metabolism. They are also regulated by transcription factors, adipoc ytokines and environmental factors. Different microRNAs form a complex regulatory network through the regulation of target gene mRNA. This paper reviews the role and the way of microRNA regulation of lipid metabolism.