肿瘤干细胞及肿瘤靶向治疗的研究进展

Research progress on tumor stem cells and tumor targeted therapy

研究发现引起肿瘤复发或转移的根源是肿瘤中一少部分具有无限增殖能力的肿瘤干细胞,其在体内长期存在并不断自我更新,使肿瘤快速增殖且侵袭、转移能力增加,药物敏感性减弱,成为临床治疗的难题。因此,深入了解肿瘤干细胞进而寻找抑制肿瘤干细胞的方法对临床靶向治疗肿瘤具有重要意义。本文从肿瘤干细胞的发现过程、生物学特性、鉴别及培养方法等方面进行了阐述,根据其特点总结针对肿瘤干细胞治疗肿瘤的方法,并重点综述抗生素治疗肿瘤干细胞的研究进展。

The root cause of tumor recurrence or metastasis is a small part of the tumor with unlimited proliferation of tumor stem cells,which can exist for a long time and continue to self-renewal causing rapid tumor proliferation and invasion,metastasis capacity,drug sensitivity,eventually resulting in the problem of weakened clinical treatment. Therefore,it is of great importance to in-depth understanding of tumor stem cells and then to seek strategies to suppress tumor stem cells in clinical targeted tumor therapy. In this paper,the discovery process of tumor stem cells,biological characteristics,identification and culture methods were described to summary a variety of methods to inhibit tumor stem cells according to their characteristics so as to treat tumor. Moreover,it focuses on the research progress on antibiotic treatment of cancer stem cells.