摘要
白细胞介素-18(interleukin-18,IL-18)是一个多肽片段,具有促进T细胞增殖、增强细胞毒性T细胞和自然杀伤细胞活性等功能。自身免疫性疾病是指机体对自身抗原发生免疫反应而导致自身组织损害所引起的疾病。IL-18在免疫调节中有着高效、广泛的作用,部分自身免疫性疾病发病与免疫系统的异常会伴随IL-18的高表达,且不同病程IL-18表达量会有规律性变化,因此IL-18可作为一种自身免疫性疾病较敏感的标志物。现对IL-18在常见自身免疫性疾病如系统性红斑狼疮、成人Still病、自身免疫性心肌炎和类风湿关节炎中的作用作一综述。
Interleukin-18（IL-18） is a peptide segment,which can promote T cell proliferation and enhance activities of cytotoxic T cells and natural killer cells.Autoimmune diseases are syndromes which are caused by body immune response to its own antigens.Studies have shown that IL-18 plays an important role in immunomodulatory.This article provides an overview on the effects of IL-18 in autoimmune diseases including systematic lupus erythematosus,adult-onset still＇s disease,autoimmune myocarditis,and rheumatoid arthritis.
作者
李慕聪
邢东明
LI Mu-cong;XING Dong-ming(School of Life Sciences, Tsinghua University, Beijing 100084, China)
出处
《微生物学免疫学进展》
2017年第6期85-88,共4页
Progress In Microbiology and Immunology
