用于癌症治疗的电荷翻转型纳米药物载体的研究进展

The Development of Nano-sized Drug Delivery Systems with Charge-reversal Properties for Cancer Therapy

电荷翻转技术的引入,可使纳米药物载体系统在正常生理环境下带负电或不带电,而在肿瘤组织微环境的刺激下带正电,因此可有效降低载体被正常细胞非特异性吞噬的可能性并可促进癌细胞对载体的吞噬,显著提高了载体对癌症的治疗能力,降低了毒副作用。为此,本文综述了电荷翻转型纳米药物载体的构建方法及电荷翻转的原理,并简单介绍了电荷翻转型药物载体的研究进展。

The application of charge-reversal properties to nano-sized drug delivery systems can make whose neutral surface or negative charged in the normal tissues but positive charged near the tumor tissues due to the stimuli of the tumor microenvironments.As a result, this method can reduce the unspecific uptake of the drug carriers by the normal cells and can enhance the ability of cell uptake by cancer cells, as well as to increase the treatment effects of the drug carriers and to reduce the side effects. In this review, we briefly introduced the methods to fabricate the nano-sized charge-reversal drug delivery systems and the principles of charge-reversal methods. And we also review the development of nano-sized charge-reversal drug delivery systems.