中石油派驻尼日尔员工G6PD活性筛查及疟疾感染的问卷调查

Investigation on G6PD activity and malaria infection in Niger Chinese employees stationed by National Petroleum Corporation

目的评估中石油派驻尼日尔员工葡萄糖-6-磷酸脱氢酶(G6PD)活性,并调查其疟疾感染情况。方法使用Care Start G6PD快速检测试剂条检测460名中石油驻尼日尔员工的G6PD活性,通过调查问卷的形式统计其疟疾感染率。结果 460名中石油驻尼日尔员工的G6PD活性均处于正常范围,可安全使用伯氨喹。接受问卷调查的426名员工分别来自CPF营地、FPF营地、Jaouw营地和炼油厂,疟疾感染率分别为15.9%、2.4%、20.6%和23.0%。驻非工作年限<5年者疟疾感染率为7.7%,驻非工作年限>10年者疟疾感染率为41.4%,即随着驻非工作年限的增加,感染疟原虫的风险也明显增加。结论中石油派驻尼日尔员工使用伯氨喹治疗是安全的,不会发生G6PD缺陷引发的急性溶血贫血。

Objective To assess the prevalence of glucose-6-phosphatedehydrogenase deficiency in Niger Chinese employees stationed by China National Petroleum Corporation （CNPC）,and to investigate the prevalence of malaria in such populations. Methods The GrPD activity of 460 CNPC employees in Niger was detected by using the CareStart G6PD kit,and the incidence of malaria was analyzed statistically in the form of questionnaires. Results The GrPD activity of 460 CNPC employees in Niger was all normal,and they were safety to use primaquine. These 426 employees were from CPF camps （n=63）,FPF camps （n=42）,Jaouw camps （n=68） and refineries （n=252） with malaria incidence rates of 15.8% ,2.4% ,20.6% and 23.0%. Of the 195 subjects who worked in Africa less than 5 years,the incidence of malaria was 7.7%,202 subjects had 5-10 years of in Africa work experience and the incidence of malaria was 29.7%,29 subjects worked in Africa more than 10 years,the incidence of malaria was 41.4%. With the increase of working years in Africa,the risk of malaria infection also increased significantly. Conclusions 460 CNPC employees in Niger were safe when they need to be treated by primaquine and would not develop acute hemolytic anemia caused by G6PD deficiency.