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Podoplanin在食管鳞状细胞癌患者中的表达及临床预后:回顾性队列研究 被引量:3

Podoplanin expression and clinical prognosis of patients with esophageal squamous cell carcinoma: A retrospective cohort study
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摘要 目的分析Podoplanin蛋白在食管鳞状细胞癌(鳞癌)患者中的表达情况,探寻其与食管鳞癌患者脉管内出现瘤栓、淋巴结转移、肿瘤分化及预后之间的关系,为减少食管鳞癌患者肿瘤复发,延长无病生存时间及总生存时间提供临床证据。方法回顾性分析2010年6月至2012年6月我院胸外科经胃镜确诊为食管鳞癌并接受手术治疗、完成随访70例患者的临床资料,其中男39例、女31例,平均年龄63.6岁。脉管瘤栓阳性35例,脉管瘤栓阴性35例。查看术后病理标本,并切取纳入该研究患者的正常食管组织(即距肿瘤边缘>5 cm的食管组织)作为对照。结果 Podoplanin在正常食管组织中阳性表达率为34.2%,在肿瘤组织中阳性表达率为62.8%;在脉管瘤栓阳性和阴性的食管鳞癌患者中阳性表达率分别为77.1%、48.6%;在淋巴结转移阳性和阴性的食管鳞癌患者肿瘤细胞内阳性表达率分别为71.9%、23.1%,差异均有统计学意义(P<0.05)。肿瘤细胞内Podoplanin表达阴性的食管鳞癌患者平均无病生存期15.2个月,明显长于肿瘤细胞内Podoplanin表达阳性的食管鳞癌患者(P<0.05)。结论临床上可将Podoplanin在肿瘤细胞、脉管内的阳性表达作为判断食管鳞癌患者预后的重要参考指标。 Objective To analyze the Podoplanin expression in patients with esophageal squamous cell carcinoma and to find out the relationship between Podoplanin expression and tumor embolus, lymph node metastasis, tumor differentiation as well as prognosis, and to provide clinical evidence for reducing the recurrence of esophageal squamous cell carcinoma and prolonging the disease-free survival and overall survival. Methods A retrospective analysis of 70 patients with esophageal squamous cell carcinoma in our hospital from June 2010 to June 2012 was conducted, including 39 males and 31 females, with a mean age of 63.6 years. Positive diagnosis of tumor thrombus was achieved in 35 patients and negative in 35 patients. Postoperative pathological specimens were examined and normal esophageal tissues (esophageal tissue more than 5 cm from the edge of the tumor) of patients were excised as a control group. Results The positive rate of Podoplanin was 34.2% in normal esophageal tissues and 62.8% in tumor tissues. The positive rate of Podoplanin expression was 77.1% and 48.6% in esophageal squamous cell carcinoma patients with or without tumor embolus, respectively. The positive rate of Podoplanin expression in tumor cells of patients with positive and negative lymph node metastasis was 71.9% and 23.1%, respectively (P〈0.05). The mean disease-free survival of patients with Podoplanin expression-negative esophageal squamous cell carcinoma was 15.2 months, which was significantly longer than that of patients with Podoplanin expression-positive esophageal squamous cell carcinoma (P〈0.05). Conclusion Podoplanin expression in the tumor cells and vessels can be an important reference index to the prognosis of patients with esophageal squamous cell carcinoma.
出处 《中国胸心血管外科临床杂志》 CAS CSCD 2018年第2期148-152,共5页 Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
关键词 食管鳞癌 脉管瘤栓 PODOPLANIN 无病生存期 Esophagus squamous cancer vasctflar tumor embolus Podoplanin disease-free survival
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