枯否细胞在乙型肝炎病毒感染过程中的作用

Role of Kupffer cells in hepatitis B virus infection

在我国,乙型肝炎病毒（HBV）感染是导致慢性肝脏疾病的最主要原因.对于慢性乙型肝炎（CHB）患者来说,HBV的清除至关重要.现行的抗HBV治疗药物主要以干扰素和核苷类似物为主.干扰素不良反应多见,其在临床上的应用有限,而核苷类似物需长期应用维持治疗.枯否细胞（KC）是肝脏主要的固有免疫细胞,大量研究表明,其在HBV感染中发挥着重要的作用.KC可以有效的抑制病毒复制,但同时也可导致免疫功能紊乱,造成病毒持续存在.通过了解KC在HBV感染中的作用机制,有助于发现新的抗病毒治疗方法.

Hepatitis B virus（HBV）infection is the main cause of chronic liver diseases in China. The clearance of HBV is important for patients with chronic hepatitis B.Current antiviral therapy includes interferon and nucleotide analogues.The adverse reactions of interferon are common which restrict its application.Nucleotide analogues need long-term maintenance treatment.Kupffer cells （KCs） are the main innate immune cells in the liver.Studies have shown that KCs play an important role in hepatitis B virus infection.It can inhibit virus replication effectively , but may also result in immune dysfunction , causing HBV persistence.Understanding the mechanism related to the role of KCs in hepatitis B virus infection may lead to a new approach of antiviral therapy.