VCAM-1、AOPP、HbA1c和FBG在二甲双胍治疗糖尿病肾病患者中的意义

The Significance of VCAM-1,AOPP,HbA1c and FBG in Metformin Treatment of Diabetic Nephropathy

目的血管细胞粘附分子-1(vascular cell adhesion molecule-1,VCAM-1)、人晚期氧化蛋白产物(advanced oxidation protein products,AOPP)、糖化血红蛋白(HbA1c)和血纤维蛋白原(fibrinogen,FBG)在二甲双胍治疗糖尿病肾病中的变化和意义。方法选取本院2015年7月至2017年7月收治的150例糖尿病肾病患者接受二甲双胍治疗3个月,治疗前后分别检测患者血清中VCAM-1、AOPP、HbA1c和FBG的水平变化。结果与对照组相比,糖尿病肾病患者体内VCAM-1、AOPP、HbA1c和FBG水平显著升高,差异具有统计学意义(P<0.05)。与常规治疗相比,患者应用二甲双胍治疗后血清VCAM-1、AOPP、HbA1c和FBG水平显著降低,差异具有统计学意义(P<0.05)。结论患者血清中VCAM-1、AOPP、HbA1c和FBG水平在二甲双胍治疗前后具有明显变化;VCAM-1、AOPP、HbA1c和FBG在糖尿病肾病的临床治疗过程中对病情的判断具有重要的提示作用。

Objective To investigate the effects of vascular cell adhesion molecule- 1 （ VCAM- 1 ）, advanced antioxidated protein products （ AOPP）, glycosylated hemoglobin （ HbA1 c） and fibrinogen （FBG） in mefformin treatment of diabetic nephropathy and their significance. Methods 150 patients with diabetic nephropathy admitted to our hospital during 2015 / 07-2017 / 07 were treated with metformin for 3 months. The levels of VCAM-1 ,AOPP, HbAlc and FBG in serum were measured before and after treatment. Results Compared with the control group, the contents of VCAM-1, AOPP, HbAlc and FBG in patients with diabetic nephropathy were significantly increased, and the difference was statistically significant（ P 〈 0.05 ）. Compared with conventional therapy, the levels of serum VCAM- 1, AOPP, HbA1 c and FBG were significantly decreased after treatment with metformin, the difference was statistically significant （ P 〈 0.05 ）. Conclusion The serum levels of VCAM-1, AOPP, HbA1 c and FBG in patients significantly change before and after metformin treatment. VCAM-1, AOPP, HbAlc and FBG in the clinical treatment of diabetic nephropathy during the process of judging the disease have important roles in the judge.