替米沙坦联合硝苯地平对EH患者的疗效及对血清中HGF、VEGF水平变化的影响

Effect of Telmisartan Combined with Nifedipine on EH Patients and Their Influence on Serum Levels of HGF and VEGF

目的分析替米沙坦联合硝苯地平对原发性高血压(EH)患者的治疗效果及对血清肝细胞生长因子(HGF)、血管内皮生长因子(VEGF)水平的影响。方法回顾性选取2014年11月至2016年10月我院收治的原发性高血压患者98例,根据治疗方法不同分为对照组和观察组。对照组患者采用硝苯地平治疗,观察组患者采用替米沙坦联合硝苯地平治疗。观察并比较两组患者疗效、超声心动图指标水平、脂联素、细胞间黏附分子-1(ICAM-1)、HGF、VEGF水平及血管弹性指标水平变化情况。结果观察组患者总有效率为92.88%,对照组为79.60%,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后LVPWT、LVEDD及IVMI水平均较治疗前改善,观察组患者治疗后LVPWT、LVEDD及IVMI水平优于对照组,差异有统计学意义(P<0.05)。两组患者治疗后脂联素水平较治疗前上升,ICAM-1、HGF及VEGF水平均较治疗前下降,观察组患者治疗后脂联素水平高于对照组,ICAM-1、HGF及VEGF水平低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后C1、C2及PWV水平均较治疗前改善,观察组患者治疗后C1、C2及PWV水平均优于对照组,差异有统计学意义(P<0.05)。结论替米沙坦联合硝苯地平治疗原发性高血压疗效确切,可改善患者左心室构造和血管弹性,降低血清HGF、VEGF水平。

Objective To analyze the effect of Telmisartan combined with Nifedipine on the treatment of patients with es- sential hypertension （ EH ） and the influence on serum bepatocyte growth factor （ HGF ） and vascular endothelial growth factor （VEGF） levels. Methods 98 cases of essential hypertension patients received in our hospital during November 2014 to October 2016 were selected retrospectively and divided into control group and observation group according to different therapeutic schemes. Patients in control group were treated with Nifedipine and patients in observation group were treated with Telmisartan combined with Nifedipine. The changes of therapeutic effect, indicators in echocardiography, adiponectin, intercellular adhesion molecule-1 （ ICAM-I ）, HGF, VEGF and vascular elasticity in the two groups were observed and compared. Results The overall response rate of observation group was 92. 88% , which is higher than 79. 60% of control group, the difference being statistically significant （P 〈 0.05）. LVPWT,LVEDD and IVMI of patients in the two groups were both improved after treatment, and furthermore, post-treat- ment LVPWT, LVEDD and IVMI of observation group was superior to those of control group, the dift^rence being statistically signif- icant（P 〈 0. 05）. Adiponectin levels of the two groups rose and ICAM-1, HGF as well as VEGF levels fell after treatment, com- pared with conditions before treatment. Post-treatment adiponectin level of observation group was higher than that of control group and post-treatment ICAM-1, HGF as well as VEGF levels of observation group were lower than those of control group, the difference being statistically significant （ P 〈 0. 05 ）. CI, C2 and PWV levels of the two groups were both improved after treatment and post-treatment C 1, C2 and PWV levels of observation group were superior to those of control group, the difference being statistically significant（ P 〈 0. 05 ）. Conclusion Telmisartan combined with Nifedipine is effective in the treatment of essential hypertension and can improve the left ventricular construction as well as vascular elasticity, reduce serum HGF and ~EGF levels of patients.