原发女性生殖系统非霍奇金淋巴瘤的临床病理分析

Clinicopathological analysis of primary non-Hodgkin＇ s lymphoma of the female reproductive system

目的 回顾分析我院收治的 28例原发女性生殖系统非霍奇金淋巴瘤的临床病理特点和治疗结果。方法 1990—2016年在我院收治的原发女性生殖系统非霍奇金淋巴瘤患者 28例。采用WHO淋巴瘤病理分类、Ann Arbor分期系统分期。共 18例（64%）患者进行了手术,27例（96%）进行了化疗、8例（29%）进行了放疗。Kaplan-Meier法计算生存率。结果 5年随访率86%。年龄 13-80岁,中位年龄56.5岁。原发卵巢者最多,共 11例（39%）,ⅣE期患者 18例（64%）,最常见病理类型是弥漫大B细胞淋巴瘤。中位生存时间23.5个月,1、3、5年OS率分别为89%、74%、59%。结论 原发女性生殖系统非霍奇金淋巴瘤临床少见,症状不典型,分期多为晚期,治疗上以手术、化疗和放疗的综合治疗手段为主。

Objective To retrospectively analyze the clinical pathological features and treatment outcomes of primary non-Hodgkin’slymphoma （NHL） of the female reproductive system. Methods A retrospective analysis was performed on the clinical data of 28 patients with primary NHL of the female reproductive system who were admitted to our hospital from 1990 to 2016. The lymphomas were classified and staged based on the WHO histological classification and the Ann Arbor staging system,respectively. Of the 28 patients,18（64%） underwent surgery,27（96%） received chemotherapy, and 8（29%） received radiotherapy. The Kaplan-Meier method was used to calculate survival rates. Results The 5-year follow-up rate was 86%.The median age was 56.5 years （13-80 years）. The ovary was involved in 11 patients （39%）. The lymphoma was staged as IVE in 18 patients （64%）.The most common pathological type was diffuse large B-cell lymphoma. The median survival time was 23.5 months. The 1-, 3-, and 5-year overall survival rates were 89%, 74%, and 59%, respectively. Conclusions Primary NLH of the female reproductive system is an extremely rare neoplastic disorder with no typical clinical symptoms and mostly diagnosed in advanced stage. The combined treatment with surgery,chemotherapy, and radiotherapy plays an important role in the treatment of the disorder.