糖皮质激素临床应用再认识

The recognition of clinical application of glucocorticoids

糖皮质激素(GCs)因具有显著的抗炎和抑制免疫的作用,故在临床上得到了广泛的应用。然而,长期使用GCs引起的不良反应及糖皮质激素抵抗(GR)一直是临床上棘手的问题。因此,探索降低GCs不良反应,提高GCs敏感性的方法成为研究的热点。文中旨在探讨降低GCs的不良反应及增加GCs敏感性的新策略。

Because of the significant anti-inflammatory and immunosuppressive effects, glucocorticoids （GCs） have been widely used in clinic However, adverse reactions caused by long-term use of GCs and glucocorticoid resistance （GR） are always trou- blesome problems in clinical department. Therefore, it is the hot point to explore the ways to reduce adverse reactions of GCs and to im- prove sensitivity of GCs. In this article, we mainly discuss new strategies of reducing adverse reactions and improving sensitivity of GCs.