不孕不育伴发抑郁患者的人格特征及其血脂水平关系

Personality characteristics and blood Lipid levels in Infertility patients with depression

目的血脂水平可能影响不孕不育患者的情绪,与人格特征存在相关性。文中探讨不孕不育伴发抑郁情绪患者的人格特征及血脂水平,进一步分析抑郁程度与两者之间的内在关系。方法选取2015年12月至2016年12月期间于华北理工大学附属唐山市妇幼保健院门诊治疗的190名不孕不育患者为研究对象,通过抑郁自评量表(Self-Rating Depression Scale,SDS)行抑郁症状测评。以患有不孕不育伴抑郁症状的患者为抑郁组,以患有不孕不育但无抑郁症状的患者为无抑郁组。测定2组患者血脂水平,包括总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C),并通过艾森克人格问卷(EPQ)对人格特征进行测评。结果抑郁组患者以轻中度抑郁为主(占64.4%),中重度抑郁约占30.0%。抑郁组患者TG、TC均明显高于无抑郁组(P<0.01)。艾森克人格各维度中,抑郁组患者神经质(N)、效度量表(L)和精神质(P)得分高于无抑郁者(P<0.05);两组外倾性(E)之间差异无统计学意义(P>0.05)。TG、E维度、P维度及L维度为抑郁程度的有效预测变量,其β系数分别为0.199、-0.240、0.424和0.220。TG与N、P、L三维度呈显著正相关(P<0.05)。结论不孕不育伴发抑郁情绪患者可能存在血脂紊乱和人格改变。TG水平和N维度、P维度得分越高,抑郁程度越重。

Objective To discuss the personality characteristics and blood lipid levels in patients with infertility and depres- sion, and further analyze the relationship between the degree of depression and the two aspects. Methods We selected 190 infertility patients and they were tested with Self-Rating Depression Scale（SDS） in Tangshan Maternal and Child Health Care Hospital Affiliated to North China University of Science and Technology from December, 2015 to December,2016. All the patients were allocated into depres- sion group （with depression symptom） and non-depression group （without depression symptom）. Blood lipid levels, including triglyc- erides （ TG）, total cholesterol （ TC ）, low density lipoprotein cholester- ol （ LDL-C ） and high density lipoprotein cholesterol （ HDL-C ） were determined and the Eysenck Personality Questionnaire（EPQ） was ap- plied to evaluate the personality traits in both groups. Results The patients in the depression group were mainly mild-to-moderate depres- sion accouting for 64.4%, and patients with moderate to severe depression accouted for approximately 30.0%.The levels of TG and TC of patients in the depression group were significantly higher than those in the non-depression group（P〈0.01 ）.The scores of neuroticism（N）, validity scale（L） and psychoticism（P） of patients in the depression group were significantly higher than those in the non-depression group, while there was no significant difference in exextra- version（E） between the two groups.TG, E dimension, P dimension and L dimension were effective predictors of depression in infertile patients, and the Beta coefficient were 0.199, -0.240, 0.424 and 0.220. Pearson partial correlation analysis showed that TG was posi- tively correlated with P, N and L dimensions. Conclusion Infertility patients with depression may have dyslipidemia and personality changes. The degree of depression is positively correlated to the level of TG and the score of P and N.