MicroRNA与慢性鼻-鼻窦炎发病机制的研究进展

Research advance of microRNA in the pathogenesis of chronic rhinosinusitis

MicroRNA（miRNA）是长度为18～22个核苷酸的非编码单链RNA分子,它广泛存在于真核细胞生物中,其介导靶基因转录后的基因沉默。慢性鼻-鼻窦炎（chronic rhinosinusitis,CRS）的特征是以鼻和鼻窦黏膜炎症为特征的一组病症,其发病机制仍未完全阐明。目前有研究发现miRNA与炎症性疾病的发生发展相关,其中也参与了CRS患者的基因调控作用。本文就CRS中miRNA的表达和功能做一综述。

Chronic rhinosinusitis（CRS）is a Common disease of otorhinolaryngology head and neck surgery,manifested as nasal-sinus mucosal chronic inflammation.However,the pathogenesis of CRS is not clear.There are studies found that microRNA（miRNA）involved in CRS gene regulation.In this review,we summarizes the expression of miRNAs in CRS,with the in-depth study of the role of miRNAs in CRS,and will further elucidates the pathogenesis of CRS.