摘要
以苯丙酮为起始原料,通过溴化、缩酮化、格氏反应制成3-苯甲酰苯丙酮,再经1,2-芳基迁移重排得2-(3-苯甲酰苯基)丙酸乙酯,直接水解得酮基布洛芬,总收率35%。
Ketoprofen was synthesized from propiophenone by bromination,
ketalformation,Grignard reaction and rearrangement with some improved condi-
tions.The overall yield was about 35%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第8期344-345,共2页
Chinese Journal of Pharmaceuticals
