摘要
目的分析年轻患者(年龄<35岁)行体外受精/卵细胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)治疗后单、双胎妊娠的不良围产期结局以及双胎妊娠的影响因素。方法回顾性分析我中心2015年1月至2016年7月获得单胎或双胎妊娠的1 321例年轻IVF/ICSI患者的临床结局和新生儿分娩情况。结果双胎组的整体流产率、早期流产率和出生体质量低于单胎组(P<0.05),中期流产率、早产率、剖宫产率和低出生体质量率显著高于单胎组(P<0.05),两组的妊娠囊丢失率和出生缺陷率差异无统计学意义(P>0.05)。冻融胚胎移植、囊胚期胚胎、双胚胎移植为年轻患者双胎妊娠的危险因素。结论双胎妊娠增加了年轻患者中期流产、早产、剖宫产和低出生体质量儿的风险。在冻融周期选择单囊胚移植是年轻患者保证高临床妊娠率的情况下减少双胎率的有效措施。
Objective To compare the perinatal outcomes between singleton and twin pregnancies and the influencing factors in young cases (age 〈 35) after in vitro fertilization/egg cell sperm injection-embryo transfer (IVF/ICSI-ET). Methods A retrospective study was performed to analysis the perinatal outcomes of the young cases after IVF/ICSI-ET from January 2015 to July 2016. Results The total abortion rate, early abortion rate and the average body weight of the twin group were significantly lower than the singleton group (P 〈 0.05) , the mid- term abortion rate, the preterm delivery rate, cesarean section rate and the low birth weight rate were opposite (P 〈 0.05 ), while the total pregnancy loss rate and the rate of birth defects were not significantly different'between the groups (P 〉 0.05 ). The frozen-thawed embryo transfer, blastocyst transfer and double-embryo transfer were the risk factors of twin pregnancy. Conclusions Twin pregnancy may increase the risk of adverse perinatal outcomes. Selective single blastoeyst transfer during frozen-thawed cycle is an effective measure for young cases, in which it can keep a balance between high clinical pregnancy rate and reducing twin pregnancy rate.
出处
《实用医学杂志》
CAS
北大核心
2018年第2期219-222,共4页
The Journal of Practical Medicine
基金
广东省自然科学基金项目(编号:2016A030313817)