卡马西平片联合苯巴比妥治疗对癫痫患者IL-1β、IL-6、Bcl-2、Bax表达的影响

Effects of carbamazepine tablets combined with phenobarbital on the expression of IL-1β, IL-6, Bcl-2 and Bax in patients with epilepsy

目的观察分析卡马西平片联合苯巴比妥治疗对癫痫患者白介素-1β(IL-1β)、白介素-6(IL-6)、抑制神经元凋亡因子(Bcl-2)、神经元凋亡因子(Bax)表达的影响。方法选取2015年1月至2016年9月于长沙市中心医院就诊的癫痫患者94例,采用随机数表法均分为观察组(n=47)与对照组(n=47),对照组患者给予卡马西平片治疗,观察组患者在此基础上联合苯巴比妥治疗,观察两组患者的临床疗效、焦虑抑郁程度、认知功能、癫痫发作次数、癫痫积分及IL-1β、IL-6、Bax、Bcl-2。结果观察组患者的治疗总有效率(89.36%)、MoCA评分[(26.54±2.21)分]、IL-6[(217.54±15.71)pg/mL]、Bcl-2[(35.78±3.64)pg/mL]明显高于对照组[76.60%、(21.27±2.15)分、(176.651±14.45)pg/mL、(29.97±3.14)pg/mL],差异均具有统计学意义(P<0.05);观察组的癫痫发作次数[(2.27±0.22)次/月]、癫痫积分[(2.27±0.22)分]、HAD评分[(2.32±0.95)分]、IL-1β(140.72±16.18)pg/mL、Bax(21.52±1.29)pg/mL明显低于对照组[(3.51±0.25)次/月、(6.34±0.83)分、(5.34±1.04)分、(169.67±17.86)pg/mL、(26.49±1.62)pg/mL,差异均有统计学意义(P<0.05)。结论马西平片联合苯巴比妥治疗能够减少患者神经细胞损伤,改善患者的焦虑、抑郁程度及认知功能,减少癫痫发作次数,临床疗效显著。

Objective To observe and analyze the effects of carbamazepine tablets combined with phenobarbital on the expression of interleukin-1 β（IL-1β）, interleukin-6（IL-6）, B-cell lymphoma 2（Bcl-2） and B-cell lymphoma-2 associated X protein（Bax） in the treatment of patients with epilepsy. Methods A total of 94 patients with epilepsy, who admitted to Changsha Central Hospital from January 2015 to September 2016, were selected and divided into the observation group（n=47） and the control group（n=47） according to random number table method. The control group were treated with carbamazepine tablets treatment, and the patients in the observation group received the treatment of carbamazepine tablets combined with phenobarbital. The clinical efficacy, anxiety and depression, cognitive function,seizure frequency, epilepsy score, IL-1β, IL-6, Bax and Bcl-2 in two groups were observed. Results The total efficiency, Montreal Cognitive Assessment（Mo CA） score, IL-6, Bcl-2 in the observation group were 89.36%,（26.54 ± 2.21）,（217.54 ± 15.71） pg/mL,（35.78 ± 3.64） pg/mL, respectively, which significantly higher than corresponding 76.60%,（21.27±2.15）,（176.651±14.45） pg/mL,（29.97±3.14） pg/mL in the control group（P0.05）. The number of seizures, epilepsy, Hospital Anxiety and Depression Scale（HAD） score, IL-1 β, Bax in the observation group were（2.27 ± 0.22）/month,（2.27±0.22）,（2.32±0.95）,（140.72±16.18） pg/mL,（21.52±1.29） pg/mL, respectively, which were significantly lower than corresponding（3.51±0.25）/month,（6.34±0.83）,（5.34±1.04）,（169.67±17.86） pg/mL,（26.49±1.62） pg/mL in the control group（P0.05）. Conclusion Carbamazepine tablets combined with phenobarbital treatment can reduce the injury of nerve cells, improve the degree of anxiety and depression and cognitive function of patients, reduce the number of seizures, with significant clinical effect.