重症肌无力伴胸腺异常的治疗案例分析

Case study of the treatment of myasthenia gravis with thymic abnormalities

目的分析扶元消癥饮结合基因检测技术治疗重症肌无力伴胸腺异常的作用。方法结合重症肌无力伴胸腺异常患者案例,入院完善实验室及器械相关检查和中医辨病辩证;根据糖皮质激素药物基因组检测和人巯嘌呤甲基转移酶基因多态性检测结果,调整中西医治疗方案。用肿瘤异常蛋白、T淋巴细胞亚群、胸部计算机断层扫描技术等结果,判断疾病转归及预后。结果和讨论筛查激素"易损"基因型患者,用扶元消癥饮结合西医治疗实现临床症状好转、客观结果好转,随访期1年未见症状复发。扶元消癥饮是治疗重症肌无力伴胸腺异常的有效方药,基因检测技术对于确定重症肌无力的中西医治疗方案有较好的辅助作用。

Objective To analysis the function of Fu-Yuan-Xiao-Zheng decoction combined with gene detection on the treatment of myasthenia gravis with thymic abnormalities. Methods A case of young female was analyzed and got all the checks done,included traditional Chinese medicine syndromes; we suit the treatment plan according to her genotype,also we judge the prognosis according to her tumor abnormal protein,T-cells,chest CT,thiopurine S-methyltransferase and so on.Results and conclusion Screen out the ＂easily vulnerable＂genotype,clinical symptoms was improved under the guidance of Fu-Yuan-Xiao-Zheng decoction and western medical therapy. A better chest CT and thyroid ultrasonic image showed no complications and recurrence in the follow up of 1 year. Fu-Yuan-Xiao-Zheng decoction can effectively treat myasthenia gravis with thymic abnormalities,gene technique can effectively assist therapy.