奥美拉唑所致245例不良反应文献分析

Literature analysis of 245 cases of adverse drug reactions induced by omeprazole

目的探讨奥美拉唑所致药物不良反应(ADR)的规律及特点,为临床合理用药提供参考。方法以"omeprazole"、"adverse effect"为主题词,检索1990~2017年Pubmed、Embase外文数据库中有关奥美拉唑致ADR的病例报告,并对患者相关情况进行统计分析。结果共收集奥美拉唑致ADR病例245例,ADR多发生在40~59岁和60~79岁年龄段,给药2~10 d及>30 d ADR好发,以消化系统、血液系统、内分泌与生殖系统及神经肌肉系统的临床表现多见。结论奥美拉唑所致ADR临床表现复杂,其发生与多种因素有关,应引起临床高度重视。

Objective To analyze the studies on adverse drug reactions( ADR) induced by omeprazole and provide reference for clinical rational drug use. Methods To set "omeprazole"and "adverse effect"as the key words,the literatures relevant to ADR induced by omeprazole in Embase and Pubmed during 1990 ― 2016 were retrieved,and the patient's information were analyzed. Results Totally 245 cases were retrieved, among which 137 cases were male( 55. 92%); occurs in 60 to 80( excluding 80) years of age( 98 cases,40%); route of administration was mainly oral administration( 236 cases,96. 33%); ADR occurrence in two time periods,which in 2-10 d and > 30 d; ADR involved organs and( or) system is extensive,mainly about the digestive system,blood system,nervous system,endocrine and reproductive system.Conclusion More attention should be paid on the increasing adverse drug reactions caused by omeprazole.