微粒体与冠状动脉粥样硬化的相关性研究进展

Advances in research on correlation between microparticle and coronary atherosclerosis

微粒体是细胞活化、凋亡过程中形成的微小颗粒。微粒体目前被认为是炎症反应的主要介质,可能在动脉粥样硬化斑块形成和随后导致急性冠脉综合征的发生、发展、形成中起作用。微粒体参与了动脉粥样硬化斑块的形成及破裂、凝血的启动以及血栓的形成,通过对微粒体的研究,可以增加对冠状动脉粥样硬化性心脏病发病机制的认识。

The microparticle is a kind of small particle formed in the process of cell activation and apoptosis. Currently,the microparticle is taken as the main medium of inflammatory reaction. However,it may also play a role of atherosclerotic plaque formation and subsequent onset,development and formation of acute coronary syndrome. Furthermore,the microparticle participates in the atherosclerotic plaque formation and rupture,coagulation startup and thrombus formation. Through the study of microparticle,the coronary atherosclerotic heart disease pathogenesis can be deeply understood.