急性脑梗死患者血清25羟维生素D水平与NIHSS评分、IMT的相关性分析

The Correlation of Serum 25-Hydroxyvitamin D with National Institutes of Health Stroke Scale Score and Intima-media Thickness in Patients with Acute Cerebral Infarction

目的:探讨急性脑梗死(ACI)患者血清25羟维生素D[25(OH)D]水平变化,分析其水平与美国国立卫生院卒中量表(NIHSS)评分、颈动脉内中膜厚度(IMT)的相关性。方法:选取2014年7月-2017年7月入住我院神经内科明确诊断为ACI的患者200例作为实验组,选取同时期门诊健康体检者200例作为对照组;分别根据入院时NIHSS评分将ACI患者分成3组(轻型组、中型组、重型组)、入院后颈动脉彩超结果将ACI患者分成4组(无狭窄组、轻度狭窄组、中度狭窄组、重度狭窄组),采用ELISA法检测入组对象血清25(OH)D水平变化。结果:(1)与对照组比较,实验组患者血清25(OH)D水平显著降低(P<0.01);(2)随着ACI病情加重,血清25(OH)D水平显著降低(均P<0.01)。(3)与无狭窄组比较,轻度狭窄组、中度狭窄组、重度狭窄组ACI患者血清25(OH)D水平均显著降低(均P<0.01),且随着颈动脉狭窄程度的增加,ACI患者血清25(OH)D水平显著降低,差异有统计学意义(均P<0.01)。(4)Pearson直线相关分析提示:ACI患者血清25(OH)D水平与NIHSS评分、IMT均呈明显负相关(r分别为-0.772、-0.558,均P<0.01)。结论:ACI患者血清25(OH)D水平显著降低,其与ACI病情严重程度相关。

Objective：To investigate the variation of serum 25-hydroxyvitamin D[25（OH）D]in the patients with acute cerebral infarction,and analysis the correlation of serum 25-hydroxyvitamin D with National institutes of health stroke scale score and intima-media thickness.Methods：There were 200 patients with acute cerebral infarction and 200 people with healthy subjects who were hospitalized in the second hospital of sanming selected for the study.The all patients with acute cerebral infarction were divide into three groups（the minor group,the medium group and the severe group）according to the National institutes of health stroke scale score;the all patients with acute cerebral infarction were divide into four groups（the No stenosis group,the minor stenosis group,the medium stenosis group and the severe stenosis group）according to the stenosis degree of carotid artery.The levels of serum 25-hydroxyvitamin D were detected with Enzyme linked immunosorbent assay.Results：（1）Compared with the healthy subjects group,the levels of serum25-hydroxyvitamin D in the acute cerebral infarction group was significantly decreased（P〈0.01）;（2）with the condition of acute cerebral infarction worsened,the levels of serum 25-hydroxyvitamin D were significantly decreased（all P〈0.01）;（3）compared with the No stenosis group,all the levels of serum 25-hydroxyvitamin D in the minor stenosis group、the medium stenosis group and the severe stenosis group were significantly decreased（all P〈0.01）,and with the stenosis degree of carotid artery increased,the levels of serum 25-hydroxyvitamin D were significantly decreased（all P〈0.01）.Correlation analysis revealed that the levels of serum 25-hydroxyvitamin D in the acute cerebral infarction group were negative correlated with National institutes of health stroke scale score and intima-media thickness（r=-0.772,-0.558,both P〈0.01）.Conclusion：The levels of serum 25-hydroxyvitamin D in the patients with acute cerebral infarction were significantly decreased,and it was closely correlated with the severity of acute cerebral infarction.