骨创伤患者创伤后血浆D-二聚体水平与创伤程度的相关性研究

Correlation between post-traumatic plasma D-dimer level and traumatic degree in bone trauma patients

目的研究骨创伤患者创伤后血浆D-二聚体水平与创伤程度的相关性。方法选取骨创伤125例住院患者作为观察组,选取同时段进行健康体检的130例体检者作为对照组。比较对照组的血浆D-二聚体水平和观察组患者伤后不同时间点(第1、3、5、10天)的血浆D-二聚体水平。将观察组125例住院患者按照创伤程度的不同分为轻伤组、重伤组、严重伤组,统计不同创伤程度的各组各个检测时间点的血浆D-二聚体水平,分析骨创伤患者创伤后血浆D-二聚体水平与创伤程度的相关性。结果观察组各个检测时间点血浆D-二聚体水平均高于对照组(P<0.05),且随着骨创伤后时间的延长,观察组血浆D-二聚体水平有逐渐下降的趋势(F=53.2,P=0.02);观察组各个检测时间点血浆D-二聚体水平严重伤组>重伤组>轻伤组(P<0.05);Person相关分析显示,骨创伤患者创伤后血浆D-二聚体水平与创伤程度呈正相关(r=0.61,P=0.03)。结论骨创伤后患者血浆D-二聚体水平快速升高,之后逐渐下降;骨创伤患者创伤后血浆D-二聚体水平与创伤程度呈正相关,临床上可将血浆D-二聚体水平作为辅助判断骨创伤患者病情轻重及预后的重要指标。

Objective To study the correlation between post-traumatic plasma D-dimer level and traumatic degree in patients with bone trauma.Methods A total of 125 bone trauma patients admitted to Dali University First Affiliated Hospital were selected as the observation group,130 healthy persons who were in the physical examination center of the same hospital at the same time were selected as the control group.The plasma D-dimer levels of the control group and the observation group at different time after injury(day 1,3,5,10)were statistically analyzed.According to the degree of trauma,the 125 patients in the observation group were assigned into three groups:mild injury group,serious injury group,severe injury group.The plasma D-dimer levels of each trauma subgroup which were examined at different time were statistically analyzed,and the correlation between post-traumatic plasma D-dimer level and traumatic degree in patients with bone trauma were analyzed.Results The levels of plasma D-dimer in the observation group were higher than those in the control group(P < 0.05).The plasma D-dimer level in the observation group decreased gradually with the prolongation of the time of bone trauma(F = 53.2,P = 0.02).The plasma D-dimer levels of the severe injury group were the highest at different time,followed by the serious injury group and the mild injury group(P < 0.05).According to the Pearson correlation analysis,there was a positive correlation between the level of plasma D-dimer and the severity of trauma(r = 0.61,P = 0.03).Conclusions The level of plasma D-dimer in patients with bone trauma increases rapidly and then decreases gradually.The level of plasma D-dimer in traumatic patients is positively correlated with the degree of trauma,and the level of plasma D-dimer can be used as an important index to judge the severity and prognosis of bone trauma patients.