中药内服与综合外用治疗阿拉伯国家慢性肾脏病患者的疗效观察

Curative effect observation of traditional Chinese medicine internal and comprehensive external use in treatment of Arabia chronic kidney disease

目的研究中药内服与综合外用治疗阿拉伯国家慢性肾脏病(CKD)患者的临床疗效,为临床治疗提供依据。方法选取阿拉伯国家CKD患者189例,按照随机数字表法将患者分为A组(95例)和B组(94例),两组均给予常规西医治疗,A组给予中药内服治疗,B组给予综合外用治疗,两组均治疗半年,比较两组临床疗效,治疗前、治疗后肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(GFR)、24 h尿蛋白定量、白蛋白、血液流变学指标及中医症状积分。结果 A组总有效率64.2%(61/95)高于B组的40.4%(38/94),差异有统计学意义(χ2=10.716,P<0.05);两组患者经过治疗后,Scr、BUN、全血高切黏度、全血低切黏度、血浆黏度、24 h尿蛋白定量的数值均出现了降低,A组患者降低的幅度大于B组患者,均差异有统计学意义(t_(Scr)=19.298,t_(BUN)=22.205,t_(全血高切黏度)=26.548,t_(全血低切黏度)=24.096,t_(血浆黏度)=107.240,t_(24 h尿蛋白定量)=107.240,P<0.05),两组患者经过治疗后,GFR、白蛋白的数值均出现了增高,A组患者增高的幅度大于B组患者,均差异有统计学意义(t_(GFR)=19.313,t_(白蛋白)=25.288,P<0.05),两组患者经过治疗后,各项中医证候评分均出现了降低,A组患者降低的幅度大于B组患者,均差异有统计学意义(t_(倦怠乏力)=22.998,t_(气短懒言)=22.426,t_(食少纳呆)=19.184,t_(腰酸膝软)=16.693,P<0.05)。结论中药内服治疗阿拉伯国家CKD具有较好的临床疗效,能明显改善患者中医症状评分,改善临床指标。

Objective To study the clinical efficacy of traditional Chinese medicine internal and comprehensive external use in treatment of Arabia chronic kidney disease(CKD),and to provide basis for clinical treatment.Methods One hundred and eighty-nine cases of Arabia CKD were selected and assigned into group A(n = 95) and group B(n = 94) according to the random number table method.On the basis of conventional western medicine treatment in both groups,group A was given traditional Chinese medicine internal use while group B was given comprehensive external use,and patients of two groups were treated for half a year.The clinical effects,serum creatinine(Scr),urea nitrogen(BUN),glomerular filtration rate(GFR),24-hour urinary protein,albumin,blood rheology index and TCM symptom score before and after treatment were compared.Results The total effective rate in group A was 64.2%(61/95),higher than that in group B(40.4%,38/94); the difference was statistically significant(χ2= 10.716,P < 0.05).After treatment,the values of creatinine,urea nitrogen,whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity and 24 h urinary protein quantification were decreased.The reduction in group A was greater than that in group B with statistically significant difference(t_(Scr)= 19.298,t_(BUN)= 22.205,t_(whole blood high shear viscosity)= 26.548,t_(whole blood low shear viscosity)= 24.096,t_(plasma viscosity)= 107.240,t_(24 h urine protein quantitative)= 107.240,P < 0.05).After treatment,the glomerular filtration rate and the albumin value were increased in both groups.The increase in group A was greater than that in group B,and the difference was statistically significant(t_(GFR)= 19.313,t_(albumin)= 25.288,P < 0.05).After treatment,the scores of TCM syndromes were decreased in both groups.The reduction in group A was greater than that in group B,and the differences were statistically significant(t_(Burnout fatigue)= 22.998,t_(Shortness of breath lazy words)= 22.426,t_(eat less dull)= 19.184,t_(backache knee soft)= 16.693,P < 0.05).Conclusions Traditional Chinese medicine internal use in treatment of Arabia CKD has good clinical curative effect,and it can significantly improve the symptoms of patients with traditional Chinese medicine scores and clinical indicators.