左奥硝唑氯化钠注射液治疗细菌性肝脓肿的临床疗效观察

Observation on clinically curative efficacy of levornidazole and sodium chloride injection in treating patients with bacterial liver abscess

目的:评价左奥硝唑氯化钠注射液治疗细菌性肝脓肿的临床有效性及安全性。方法:选取医院收治的经筛选符合需抗厌氧菌治疗的94例细菌性肝脓肿患者,按照数表法将其随机分为观察组和对照组,每组47例。观察组给予静脉滴注左奥硝唑氯化钠注射液,对照组给予静脉滴注奥硝唑注射液,两组用药剂量均为0.5 g,2次/d,5～10 d为1个疗程。比较两组患者用药后的临床疗效、细菌学疗效和不良反应发生率。结果:观察组临床有效率和细菌清除率分别为95.74%和93.33%;对照组分别为89.36%和88.23%,两组比较差异无统计学意义(x^2=0.62,x^2=1.30;P>0.05)。观察组平均住院天数为13.47 d,对照组则为14.86 d,差异无统计学意义(t=0.96,P>0.05)。药物治疗后观察组胃肠道反应、过敏反应及肝功能异常等不良反应发生率低于对照组,但两组比较差异无统计学意义(x^2=0.26,x^2=0.51,x^2=0.51;P>0.05);观察组中枢神经系统不良反应率为0,显著低于对照组的14.89%,差异有统计学意义(x^2=5.56,P<0.05)。结论:左奥硝唑用于治疗细菌性肝脓肿有效、安全,具有较高的临床应用价值。

Objective To evaluate the clinical efficacy and safety of Levornidazole and sodium chloride injection in treating patients with bacterial liver abscess. Methods： 94 patients with bacterial liver abscess who need anti-anaerobion treatment were enrolled in this study. And all of them were divided into observation group （47 cases） and control group （47 cases）. The patients of observation group received intravenous drip infusion of Levornidazole and sodium chloride injection, while patients of control group received intravenous drip infusion of Omidazole injection. The dosage of two groups was 0.5g, 2 times/d, 5-10d per a course. The clinical efficiency, bacteriology efficiency and the occurrence rate of adverse reaction between two groups were compared and researched. Results： The differences of clinically effective rate and clearance rate of bacteria between observation group （95.74% and 93.33%） and control group （89.36% and 88.23%） were not significant （x^2=0.62, x^2=1.30, P〉0.05）. The difference of average hospital stay time between observation group （13.47 d） and control group （14.86 d） also was no significant （t=0.96, P〉0.05）. After the drug therapy, the occurrence rates of adverse reactions, included of gastrointestinal reaction, anaphylaxis and abnormal liver function, of observation group was no significantly lower than that of control group （x^2=0.26, x^2=0.51, x^2=0.51, P〉0.05）. While the adverse reaction rate of central nervous system of observation group （0） was significant lower than that of control group（14.89%） （x^2=5.56, P〈0.05）. Conclusion： Levornidazole treating the bacterial liver abscess can obtain significant efficacy and safety, and it has higher clinical application value.