Oct4、Stat3在卵巢浆液性/黏液性囊腺癌中的表达及临床意义

The expressions and clinical significance of Oct4 and Stat3 in ovarian serous or mucinous cystadenoma or in cystadenocarcinoma

目的:探讨Oct4、Stat3在卵巢浆液性/黏液性囊腺癌中的表达及其相关性。方法:应用组织芯片,采用免疫组化SP法检测60例卵巢浆液性/黏液性囊腺癌组织中Oct4、Stat3的表达。结果:Oct4在卵巢浆液性/黏液性囊腺瘤中的阳性表达率为35.0%(7/20),低于卵巢浆液性/黏液性囊腺癌中的83.3%(50/60),两者有显著统计学差异(P<0.01)。卵巢浆液性/黏液性囊腺癌中Oct4的阳性表达率与患者年龄、临床分期、组织学分化程度、患者组织学类型均无相关性(P>0.05)。Stat3在卵巢浆液性/黏液性囊腺癌阳性表达率为71.7%(43/60),明显高于卵巢浆液性/黏液性囊腺瘤中的35.0%(7/20),两者有显著统计学差异(P<0.01)。Stat3在Ⅰ、Ⅱ期癌中的阳性表达率低于Ⅲ、Ⅳ期癌(P<0.05),在中、低分化癌中的阳性表达率高于高分化癌(P<0.05),与患者组织学类型无关。卵巢浆液性/黏液性囊腺癌中Oct4表达与Stat3表达呈正相关(P<0.05)。结论:Oct4、Stat3高表达可能与卵巢浆液性/黏液性囊腺癌的发生、发展密切相关,且相互间可能具有协同作用。

ObjectiveTo explore the expression of Oct4 and Stat3 in ovarian serous or mucinous cystadenoma or in cystadenocarcinoma and the clinicopathologic significance. Methods： The expressions of Oct4 and Stat3 were detec-ted by tissue microarray combined with SP immunohistochemistry in ovarian serous or mucinous cystadenoma or in cystadenocarcinoma. Results：The positive expression rate of Oct4 was 35.0% （7/20） in ovarian serous or mucinous cystadenoma,which was less than the 83. 3% （50/60） in cystadenocarcinoma. There was significant difference be-tween them （P 〈0.01） . But the rate of Oct4 expression in carcinoma was not associated with age,clinical stage,his-tological differentiation and histological types （P 〉0. 05）. The positive expression rate of Stat3 was 35. 0% （7/20） in ovarian serous or mucinous cystadenoma, which was less than the 71. 7% （43/60） in cystadenocarcinoma. There was significant difference between them （P 〈 0. 01 ）. The rate of Stat3 expression in carcinoma of grade I , II was lower than grade HI,IV （ P 〈 0. 05 ）. The positive expression rate of Stat3 was evidently higher in moderately and poorly differentiated carcinoma than that of the well differentiated group （P 〈0.05） ,and was not associated with his-tologic types. In ovarian serous or mucinous cystadenocarcinoma, there was a significantly positive correlation between Oct4 and Stat3 expression （P 〈0. 05） . Conclusion： The overexpression of Stat3 and Oct4 may play an important role in the development and progression of ovarian serous or mucinous cystadenocarcinoma.