肺原发性脑膜瘤1例并文献复习

Primary meningioma of the lung of 1 case and literature review

目的:探讨肺原发性脑膜瘤的临床病理特征、诊断和鉴别诊断、治疗及预后。方法:回顾性分析1例肺原发性脑膜瘤患者的临床资料、组织病理形态、免疫组织化学染色、治疗及随访结果,并回顾相关文献。结果:光镜下肿瘤细胞呈脑膜上皮样,细胞异型性不明显,未见明确核分裂象。免疫组织化学染色结果显示肿瘤细胞Vimentin(+)、PR(+)、EMA灶性(+)、Ki-67(+)约1%~3%。SMA、S-100、CK-P、calponin、CD34、HMB-45、Melan-A、cg A、syn、CD56、Napin-A、TTF-1、PAS均为阴性。染色结果均支持良性脑膜瘤的诊断。结论:肺原发性脑膜瘤十分少见,掌握其临床病理特征对该病的诊断、鉴别诊断、治疗及预后具有重要意义。

Objective:To explore the clinicopathological features,diagnosis and differential diagnosis,treatment and prognosis of primary meningioma of the lung.Methods:The clinical data,histopathology,immunohistochemical staining,treatment and follow-up results of 1 case of primary meningioma of the lung were reviewed,and the related literature was reviewed.Results:Under the light microscope,the tumor cells showed the epithelioid of the meninges,and the heteromorphosis of the cells was not obvious,and there was no clear nuclear division.The results of immunohistochemical staining showed that tumor cells Vimentin(+),PR(+),EMA(+)and Ki-67(+) about 1% ~ 3%.SMA,S-100,CK-P,calponin,CD34,HMB-45,Melan-A,cg A,syn,CD56,Napin-A,TTF-1 were all negative.The staining results supported the diagnosis of benign meningioma.Conclusion:Primary meningioma of the lung was very rare,it was important for the diagnosis,differential diagnosis,treatment and prognosis of the disease to master the clinicopathological features.