摘要
目的运用磁共振成像技术探讨侧面面肌痉挛(hemifacial spasm,HFS)患者是否存在脑功能和结构上的改变。材料与方法结合静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-f MRI)和基于体素的形态学分析方法(voxel-based morphometry,VBM)观测33例偏侧面肌痉挛患者与33例性别匹配的健康对照之间的自发性脑活动和脑结构上的差异。磁共振数据采用Matlab和SPM12软件进行分析,统计分析采用双样本t检验,统计阈值为体素水平P<0.005,团块水平经过FWE检验矫正,P<0.05,大于30个体素的团块将被报道。结果静息态脑功能结果显示,HFS患者在小脑Ⅵ小叶区的局部一致性(regional homogeneity,Re Ho)值显著低于健康对照;VBM结果显示,HFS患者在小脑Ⅵ小叶区灰质体积显著低于健康对照。结论 HFS患者的小脑Ⅵ区存在脑功能和脑结构的改变,提示小脑异常可能和HFS患者持续面部肌肉不自主抽搐的状态有关。
Objective: Using magnetic resonance imaging technique to explore the change of brain function and structure in patients with hemifacial spasm(HFS). Materials and Methods: This paper combined resting-state functional magnetic resonance imaging(rs-f MRI) and voxel-based morphometry(VBM) to investigate the spontaneous brain activity and structural differences between the 33 patients with HFS and the 33 healthy controls of gender matching. And the MRI data were analyzed by SPSS, SPM12 and Matlab. Two-sample t-tests were used to determine betweengroup differences and thresholds at P0.005(voxel level), and FWE were corrected to P〈0.05 at the cluster level. The surviving clusters 30 were reported. Results: Compared to the controls, the patients with HFS exhibited significantly decreased regional homogeneity(Re Ho) value in the cerebellum lobule Ⅵ, and decreased gray matter volume in the cerebellum lobule Ⅵ too. Conclusions: Our results showed that patients with HFS exhibited function and structure alteration in the cerebellum lobule Ⅵ, which would play an important role in pathology of HFS.
作者
陆海锋
张绮婷
张记磊
王梦星
徐帅
秦朝霞
史妍慧
何欣威
杜小霞
刘建仁
LU Hai-feng;ZHANG Qi-ting;ZHANG Ji-lei;WANG Meng-xing;XU Shuai;QIN Zhao-xia;SHI Yan-hui;HE Xin-wei;DU Xiao-xia;LIU Jian-ren(Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China;Department of Neurology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China)
出处
《磁共振成像》
CAS
CSCD
2018年第1期38-42,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
国家自然科学基金(编号:81571658)
上海市科学技术委员会项目(编号:14JC1404300)
上海申康医院发展中心"预防和控制慢性病项目"(编号:SHDC12015310)
上海市教育委员会高峰临床医学基金资助项目(编号:20161422)
上海交通大学临床研究项目(编号:DLY201614)
上海市科委生物医药重点项目(编号:16411953100)~~
关键词
面部单侧痉挛
小脑
磁共振成像
比较研究
Hemifacial spasm
Cerebellum
Magnetic resonance imaging
Comparative study