兰索拉唑联合多潘立酮治疗反流性食管炎的临床疗效评价

Evaluation of Clinical Efficacy of Lansoprazole Combined With Domperidone in the Treatment of Reflux Esophagitis

目的研究兰索拉唑联合多潘立酮治疗反流性食管炎的临床疗效评价及安全性。方法回顾性分析并纳入2016年3月—2017年8月68例反流性食管炎病例,根据随机数字表法进行分组。对照组采用雷尼替丁联合多潘立酮治疗,观察组采用兰索拉唑联合多潘立酮治疗。对两组患者治疗前后SAS评分、反流性食管炎症状积分、尼平消化不良指数和反流性食管炎治疗总有效率、药物安全性进行比较。结果观察组患者治疗前SAS评分、反流性食管炎症状积分、尼平消化不良指数和对照组对比,差异无统计学意义,P>0.05;观察组患者治疗后SAS评分、反流性食管炎症状积分、尼平消化不良指数均优于对照组,P<0.05。结论兰索拉唑联合多潘立酮治疗反流性食管炎的临床疗效确切,可减轻患者不良情绪,改善临床症状,且安全性高。

Objective To study the clinical efficacy and safety of lansoprazole combined with domperidone treatment of reflux esophagitis. Methods 68 cases with reflux esophagitis from March 2016 to August 2017 were retrospectively analyzed and divided into different groups according to the random digital table. The control group used ranitidine combined with domperidone treatment, observation group were treated with lansoprazole combined with domperidone treatment. before and after treatment, the SAS score, reflux esophagitis symptom score, genipin dyspepsia index and reflux esophagitis treatment efficiency, drug safety between two groups were compared. Results To observe the SAS score before treatment, reflux esophagitis symptom score, genipin dyspepsia index control group and contrast group, the difference was not statistically significant, P〈0.05; the observation group after treatment SAS score, reflux esophagitis symptom score, genipin dyspepsia index were better than the control group, P〈0.05. Conclusion Clinical efficacy of lansoprazole combined with domperidone in the treatment of reflux esophagitis is effective, can alleviate the negative emotions of patients, improve clinical symptoms, and high safety.