新生儿肺炎病原菌分布及耐药性研究

Study on Distribution and Drug Resistance of Pathogenic Bacteria of Neonatal Pneumonia

目的研究新生儿肺炎病原菌分布及耐药性情况。方法将2015年9月—2016年9月在本院进行治疗的199例新生儿肺炎患儿选为本次研究对象,分析患儿痰液中病原菌的检出情况,药敏试验的结果,观察患儿病原菌的耐药情况。结果收集的新生儿肺炎患儿中,共检出阳性菌112例,阳性率为56.28%;共分离出病原菌存在122株,革兰阴性菌占72.13%、革兰阳性菌占26.23%、真菌占1.64%;革兰阳性菌中,头孢类抗菌药物的耐药性较高;革兰阴性菌中,对氨苄西林、氨曲南及头孢他啶类的耐药性较高。结论对于新生儿肺炎病原菌的分布情况以及分析发现,其格兰阴性菌对于氨苄西林、氨曲南及头孢类抗菌药物的耐药性较强,对于亚胺培南以及他巴唑坦等具有较高的敏感度,临床应选择该类药物进行治疗。

Objective To study the distribution and drug resistance of the pathogenic bacteria of neonatal pneumonia. Methods 199 cases of neonatal pneumonia from September 2015 to September 2016 in our hospital were selected as the subject of this study. The detection of pathogenic bacteria in the sputum of children and the results of drug sensitivity test were used to observe the drug resistance of the pathogenic bacteria in the children. Results Among the children with neonatal pneumonia, 112 cases of positive bacteria were detected, the positive rate was 56.28%. 122 strains of pathogenic bacteria were isolated, gram-negative bacteria accounted for 72.13%, Gram-positive bacteria accounted for 26.23%, and fungi accounted for 1.64%. Among gram-positive bacteria, the drug resistance of cephalosporins was high. Among Gram-negative bacteria, the resistance to ampicillin, amamethasone and ceftazidime was higher. Conclusion The distribution of bacteria causing neonatal pneumonia and analysis found that the gram negative bacteria for ampicillin, aztreonam and cephalosporin antibiotics drug resistance to imipenem and strong, methimazoleTanzania has higher sensitivity, the clinical should choose the drugs for the treatment of.