血小板减少症患者血小板参数变化特征的研究

Study on changes of platelet parameters in patients with thrombocytopenia

目的研究血小板减少症的病例构成及相应血小板参数的变化特征。方法收集该院2016年9月14日至2017年2月20日除血液病、肿瘤患者以外的所有血小板计数小于100×10~9/L的340例患者,另随机收集该院同期的健康者资料50例。血小板减少患者按主要诊断或原发病分组,健康者作为健康对照组。对各组平均血小板体积进行比较,并对各患者组治疗前后血小板计数、平均血小板体积进行比较。结果血小板参数在不同疾病中呈现不同特征的改变,在不同疾病治疗中也有不同的改变,差异均有统计学意义(P<0.05)。结论血小板参数发生变化时应结合病例诊断、病情进展,对实验室结果进行判断和解读。同时血小板参数变化可作为临床诊断、治疗的依据。

Objective To study the rull of platelet parameters′change of all kinds of thrombocytopenia cases（Except for cancer and hematological diseases）,so that the clinical laboratory staff can more accurately determine and interpret the results of platelet parameters,also provide clinicians with more treatment and observation indicators.Methods Collected case data from September 14,2016 to February 20,2017 except for patients with hematologic diseases,cancer patients,with platelet counts less than 100×10~9/L,randomly collected data of 50 healthy persons.Thrombocytopenia cases were grouped according to their main diagnosis or primary disease,and healthy persons as control group.The degree of thrombocytopenia was classified in each group,and the mean platelet volume compared with that of healthy control group;The platelet count and mean platelet volume were compared before and after treatment in each group;The significance of the results was observed and the test level was P=0.05.Results Platelet parameters in different diseases will show different characteristics and different changes in the treatment.Conclusion The changes of platelet parameters should be combined with case diagnosis and disease progression,and then,the changes of platelet parameters can provide more evidence for clinical diagnosis and treatment.