自贡地区妊娠期甲状腺功能血清指标生物参考区间

Biological reference interval of serum thyroid function during pregnancy in Zigong area

目的建立自贡地区妊娠期甲状腺功能血清指标生物参考区间。方法依据美国临床生化研究院(NACB)标准,结合妊娠结局筛选出正常妊娠女性568例及非妊娠女性186例,分别进行甲状腺过氧化物酶抗体(TPOAb)、促甲状腺素(TSH)及游离甲状腺素(FT4)检测。结果妊娠组各期TSH和FT4总体不服从正态分布。TSH于T1期降低,8―12周为最低点,然后逐渐上升。FT4于T1期升高,之后下降,18―26周下降明显。该地区TSH生物参考区间:T1期0.06~4.37mIU/L,T2期0.27~4.20mIU/L,T3期0.65~5.73mIU/L。FT4生物参考区间:T1期6.51~13.06pmol/L,T2期4.25~10.54pmol/L,T3期3.86~9.13pmol/L。结论该地区参考区间与国内其他地区参考区间相比,存在一定差异。建立妊娠期相应检测体系的甲状腺功能生物参考区间有助于提高妊娠期甲状腺疾病的诊治能力。

Objective To establish the biological reference interval of serum thyroid function during pregnancy in Zigong area.Methods Based on the standard of NACB,combined with the pregnancy result,568 cases of normal pregnant women and 186 cases of non pregnant women were selected.Thyroid peroxidase antibody（TPOAb）,thyrotropin（TSH）and free thyroxine（FT4）were detected respectively.Results The pregnancy data didn′t match normal distribution.TSH decreased in the T1 phase,got the rock bottom in 8―12 weeks and then gradually increased.FT4 increased in the T1 phase and then decreased,significantly in 18―26 weeks.Conclusion：In Zigong area,the TSH biological reference interval as follows：0.06-4.37 mIU/L in T1 stage,0.27-4.20 mIU/L in T2 stage,0.65-5.73 mIU/L in T3 stage;the FT4 biological reference interval as follows：6.51-13.06 pmol/L in T1 stage,4.25-10.54 pmol/L in T2 stage,3.86-9.13 pmol/L in T3 stage.Conclusion There are certain differences in TSH and FT4 biological reference interval during pregnancy in Zigong area compared with other areas in China.To establish corresponding detection system of biological reference interval of thyroid function during pregnancy helps to improve the ability of treatment of thyroid disease during pregnancy.