蛋白C、蛋白S活性与进展性脑梗死的相关性研究

Relationship between activities of protein C,protein S and progressive cerebral infarction disease

目的研究蛋白C(PC)、蛋白S(PS)活性与进展性脑梗死疾病的相关性。方法选择2015年1月至2017年2月该院就诊的脑梗死患者110例,根据临床神经功能缺损程度评分进行分组,进展性脑梗死组38例,非进展性脑梗死组72例,选取同期健康体检者20例作为对照组。检测3组研究对象的血浆PC、PS活性并进行比较。结果进展性脑梗死组患者PC、PS活性明显低于非进展性脑梗死组和对照组,差异有统计学意义(P<0.05),非进展性脑梗死组与对照组比较,差异无统计学意义(P>0.05)。结论进展性脑梗死患者机体的PC系统被激活,血浆PC、PS被消耗是血栓形成和加重损伤的重要环节,因此,通过监测PC、PS活性变化为临床诊断提供重要的理论依据。

Objective To explore the relationship between activities of protein C（PC）,protein S（PS）and progressive cerebral infarction.Methods From January 2015 to February 2017,110 patients with cerebral infarction in our hospital were selected.According to the clinical neurological deficit score（NDS）,38 cases of progressive cerebral infarction group,72 cases of non-progressive cerebral infarction group,20 cases of healthy physical examination were selected as the control group.The activity of PC and PS in 3 groups were detected and compared.Results Activities of PC and PS in progressive cerebral infarction were significantly lower than those in non-progressive cerebral infarction and in control group（P〈0.05）.There was no significant difference between the non-progressive cerebral infarction and control group in activities of PC and PS（P〉0.05）.Conclusion Protein C system is activated in progressive cerebral infarction,PC is consumed that it is an important link in thrombosis and aggravate the damage,there by detecting changes in PC and PS activity is an effective basis for progressive cerebral infarction in clinical.