表皮生长因子受体(EGFR)酪氨酸激酶抑制剂厄洛替尼的合成工艺研究进展

Progress in the synthesis of erlotinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor

当前对一种小分子的络氨酸激酶抑制剂的研究比较广泛,其作用是可以对表皮的生长因子受体产生一直的作用,其中厄洛替尼就是其中之一。主要综述了厄洛替尼的合成工艺,并对各合成方法的优缺点进行了评述。

Erlotinib is a small molecule tyrosine kinase inhibitor that directly inhibits the epidermal growth factor receptor.A large number of scientific papers about erlotinib synthesis were reported in recent years.The synthesis of erlotinib has been reviewed in this paper.The advantages and disadvantages of various synthesis methods were briefly analyzed.