肿瘤免疫细胞治疗研究进展

Research Progress in Immune Cell-mediated Cancer Therapy

肿瘤免疫细胞治疗是一种新型的肿瘤治疗模式,属于肿瘤免疫治疗范畴,旨在通过调节机体的免疫细胞激活状态达到治疗肿瘤的目的.随着肿瘤免疫学理论和技术的发展,肿瘤免疫细胞治疗在血液系统肿瘤和实体瘤的临床治疗上均取得了显著的疗效,有望成为继手术、化疗、放疗和靶向治疗后恶性肿瘤治疗领域的又一场革新.本文仅就肿瘤免疫细胞治疗中以嵌合抗原受体T细胞、自然杀伤细胞以及巨噬细胞为核心的免疫细胞治疗技术的国内外研究情况进行综述.

Immune cell-mediated cancer therapy is an innovative treatment for cancers, which belongs to tumor immuno-therapy and aims to treat tumor through regulating the immune response. Immune cell-mediated cancer therapy has achieved remarkable clinical effects on both hematological malignancies and solid tumors with the development of tumor immu-nological theory and technology. It might make great advancements in cancer treatment after surgery, chemotherapy,radiotherapy and targeted therapy. Here we summarized the research progress in immune cell-mediated cancer therapy using chimeric antigen receptor（CAR）T cells, natural killer（NK）cells or macrophage.