儿茶素、槲皮素和葡萄籽原花青素的协同抗辐射作用

Synergyetic Anti-radiation Effect of Catechin,Quercetin and Grape Seed Procyanidins

通过建立体外AHH-1淋巴细胞辐射损伤模型,研究儿茶素、槲皮素和葡萄籽原花青素之间的协同抗辐射作用.结果表明:当儿茶素质量浓度为10μg/mL和槲皮素质量浓度为5μg/mL时,儿茶素质量浓度为10μg/mL和原花青素质量浓度为15、25、30μg/mL时,槲皮素质量浓度为5μg/mL和原花青素质量浓度为25μg/mL时,槲皮素质量浓度为10μg/mL和原花青素质量浓度为20、25μg/mL时,两物质间皆具有协同抗辐射作用.当儿茶素质量浓度为10μg/mL时,槲皮素质量浓度为15、20μg/mL以及原花青素质量浓度为10、20μg/mL时,儿茶素分别与槲皮素、原花青素存在拮抗作用.当槲皮素质量浓度为5μg/mL和原花青素质量浓度为20μg/mL时,当槲皮素质量浓度为10μg/mL和原花青素质量浓度为15μg/mL时,当槲皮素质量浓度为15μg/mL和原花青素质量浓度为15、20、25μg/mL时,原花青素与槲皮素皆存在拮抗作用.因此,在适量浓度范围内儿茶素、槲皮素和原花青素之间具有协同、拮抗抗辐射作用,这一研究发现对开发抗辐射功能食品具有指导意义.

The present study investigated the synergetic anti-radiation effect of catechin, quercetin and procyanidins in the AHH-1 lymphocytes radiation damage model. The results show that when the concentration of catechin and quercetinis 10,and 5,μg/mL, or the concentrations of catechin and procyanidins is 10 and 15 or 25 or 30 μg/mL, or the concentration of quercetin and procyanidins is 5 and 25 μg/mL, or the concentration of quercetin and procyanidins is 10 and 20 or 25 μg/mL,the two substances have synergetic anti-radiation effect. When the concentration of catechin and quercetin is 10 and 15 or 20μg/mL, or the concentration of catechin and procyanidins is 10 and 10 or 20 μg/mL, catechin has antagonistic effects on quercetin and procyanidins respectively. When the concentration of quercetin and procyanidins is 5 and 20 μg/mL, or the concentration of quercetin and procyanidins is 10 and 15 μg/mL, or the concentration of quercetin and procyanidins is 15 and 15 or 20 or 25 μg/mL, there is antagonism between the two substances. This research plays an important role in the develop-ment of anti-radiation functional food.