摘要
脊髓损伤可导致不同程度的躯体及自主神经功能障碍,严重影响患者的生活质量。本文介绍脑源性神经营养因子(BDNF)对脊髓损伤后的功能恢复促进作用及神经生物学效应,包括神经保护、神经可塑性、神经炎症过程调节等;以及BDNF在脊髓损伤后的不良影响,如导致神经病理性疼痛和痉挛状态等。
Spinal cord injury(SCI) can lead to varying degrees of somatic and autonomic dysfunction and seriously affect the quality of life of patients. The neurobiology and function promotion effects of brain-derived neurotrophic factor(BDNF) after SCI have been extensively studied, including neuroprotection, neuroplasticity and process regulation of neuroinflammation, etc., as well as functional recovery. However, the adverse effects of BDNF after SCI, such as neuropathic pain and spasticity, were also studied.
出处
《中国康复理论与实践》
CSCD
北大核心
2018年第2期160-164,共5页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金面上项目(No.81672258)
苏州科学技术局民生科技项目(No.SYS201785)~~
