急性内毒素血症对犬肝肾功能的影响

Effect of Acute Endotoxaemia on Hepatic and Renal Function of Dog

[目的]研究急性内毒素血症对犬肝肾功能的影响。[方法]以5只健康的犬作研究对象,建立犬内毒素血症模型。分析注射前2.0 h、注射后0.5、1.0、2.0、4.0、6.0、24.0、36.0 h血清指标。[结果]各犬在给予LPS后20 min即有临床症状出现,至24.0 h稍有缓解;血清ALT、AST、BUN和CRE的活性均随时间的变化先升高后降低,其中血清ALT值自0.5 h开始呈现持续性升高,至6.0 h逐渐下降的迹象,AST的活性变化显著(P<0.05);血清BUN值自0.5 h开始呈现持续性升高,至6.0 h逐渐见下降迹象,Cre的含量变化显著;白蛋白先下降后上升,最后恢复正常,总蛋白也呈现先降低后上升的现象,但其在36.0 h时的含量高于正常值。[结论]该研究可为犬急性内毒素血症的早期预防、治疗以及疗效观察提供参考。

[ Objective ] The aim is to study effect of acute endotoxaemia on hepatic and renal function of dog . [ Method ] Using 5 heathy dogs as test research object,endotoxaemia model of dog was established. Serum indexes were analyzed before injecting for 2. 0 h,and ater injecting for 0 . 5 h,1. 0 h,2. 0 h-N4. 0 h,6. 0 h,24. 0 h,36. 0 h. [ Result] Clinical symptoms of dog became to appear after injectingClinical symptoms relieved ater24.0 hours . Activity of ALT, AST, BUN and CRE increased firstly then mong them,ALT staried to continuously elevate after injecting LPS for 0. 5 hours,then decrease at 6. 0 h. Activity variation of AST was signifi- cant（P 〈0. 05） ;BUN started to continuously decrease ater injecting LPS for 0. 5 hours,then increase at 6. 0 h. Activity variation of AST was significant（P 〈0. 05） ;Cre content changed significantly. Albumin first increased then decreased,finally, returned to normal. Total protein also presented an first increasing then decreasing trend,content was higher than the normal value for 36. 0 hours. [ Conclusion ] The research can provide reference for early prevention, treatment and observation of curative effect of acute endotoxaemia .