“代谢健康型肥胖“存在吗?

Does Metabolically Healthy Obesity Exist?

肥胖是很多代谢疾病的危险因素。有些人达到肥胖的诊断标准,但是并未伴随糖尿病、高血压、高脂血症、胰岛素抵抗等代谢异常,这种肥胖亚型被称为"代谢健康型肥胖"(metabolically healthy obese,MHO)。本综述主要讨论MHO的诊断标准、MHO的可能机制、MHO是否为长期存在的稳定状态以及MHO与心血管-代谢疾病风险和死亡率的关系、是否应干预MHO等内容,旨在回答MHO是否存在的问题。

Obesity is a risk factor for lots of metabolic disturbances. However, there is a subset of obese subjects who have normal metabolic profiles, and they have been identified as the metabolically healthy obese （MHO）. This review will discuss the diagnosis of MHO, the possible underlying mechanisms, whether MHO stay healthy as the years pass, the cardiovascular-metabolic diseases risk and mortality in MHO, whether MHO improve after intervention.