鱼油软胶囊辅助改善记忆功能研究

Effect of fish oil soft capsule on memory improvement

研究鱼油软胶囊辅助改善记忆功能。将120只SPF级雄性昆明种小鼠随机分为对照组和鱼油软胶囊低、中、高剂量组,每日分别灌胃给予0、0.075、0.150 g/kg和0.450 g/kg鱼油软胶囊内容物,连续30 d后进行水迷宫试验、避暗试验和跳台试验。结果表明:水迷宫试验中各剂量组小鼠到达终点的时间和到达终点前的错误次数均少于对照组,高剂量组与对照组比较差异有显著性(P<0.05);避暗试验中低、中剂量组小鼠进入暗室的动物数与对照组比较,差异无显著性(P>0.05),高剂量组小鼠进入暗室的动物数与对照组比较,差异有显著性(P<0.05);跳台试验中各剂量组小鼠训练时跳下平台的潜伏期与对照组比较,差异无显著性(P>0.05),高剂量组小鼠测验时跳下平台的潜伏期与对照组比较,差异有显著性(P<0.05)。研究表明,鱼油软胶囊具有辅助改善记忆功能。

The effect of fish oil soft capsule on memory improvement was studied. 120 male Kunming mice of SPF were randomly divided into four groups ： control group and low - , middle - and high - dose groups, and each group was administrated daily with fish oil soft capsule content O, 0. 075, 0. 150, 0. 450 g/kg respectively for 30 d. Then the water maze test, step - through test and step - down test were carried out. The results showed that in water maze test, the time and errors reaching the final point of mice in each dose group were less than that in control group, and high -dose group was significantly dif- ferent from control group （ P 〈 0.05 ）. In the step - through test, the number of animals entering the darkroom in low - and middle - dose groups were not significantly different from that in control group （ P 〉 0.05 ）, while for high - dose group, it was significantly different from that in control group （ P 〈 0. 05）. In the step - down test, the step - down latency of mice during training in each dose group was not significantly different from that in control group （ P 〉 0.05）, and the step - down latency of mice dur- ing test in high - dose group was significantly different from that in control group （ P 〈 0.05）. So fish oil soft capsule had function of improving memory improvement.