射频消融治疗局部晚期胰腺癌的研究进展

Research progress of radiofrequency ablation treatment of locally advanced pancreatic cancer

胰腺癌作为一种常见的消化系统肿瘤,其恶性程度高,且早期多无明显的临床症状与体征,诊断困难,确诊时往往已有远处转移,丧失了手术机会。目前,局部晚期胰腺癌患者,首选以吉西他滨为基础药物的全身化疗,而射频消融(radiofrequency ablation,RFA)作为一种新型姑息性治疗手段,主要适用于无远处转移病灶,且原发病灶无法手术切除,或对化疗不敏感的局部晚期胰腺癌患者。RFA具有微创性、精准性以及大量的已被临床前和临床研究证实治疗局部晚期胰腺癌的安全性与有效性。本文就RFA治疗局部晚期胰腺癌的现状及研究进展进行相关综述。

The pancreatic cancer is one of the most common digestive neoplasm with difficult early diagnosis and poor prognosis,which is considered as the most malignant tumor.In reality,patients always have no obvious clinical symptoms before diagnosis,and they often lose the chance of operation because of distant metastases at diagnosis.Currently,gemcitabine-based chemotherapy has became the first choice to patients with locally advanced pancreatic cancer.Nowadays,radiofrequency ablation as a new treatment,is mainly for patients in locally advanced pancreatic cancer with non-metastatic,unresectable lesions,or insensitive to chemotherapy.Due to its minimal invasion and accuration,a large number of preclinical experiments and clinical studies have confirmed that radiofrequency ablation shows its safety and efficacy to locally advanced pancreatic cancer,which becomes more and more popular.This paper aims to discuss the current situation and advancement in radiofrequency ablation treatment of locally advanced pancreatic cancer.