C反应蛋白和降钙素原检测在重症慢性阻塞性肺疾病患者中的临床应用价值

The clinical value of C reactive protein and procalcitonin in patients with severe chronic obstructive pulmonary disease

目的:研究C反应蛋白和降钙素原检测在重症慢性阻塞性肺疾病患者中的临床应用价值。方法:选择重症慢性阻塞性肺疾病患者269例,根据患者的血清降钙素原水平分为高水平组(降钙素原≥0.5μg/L)、低水平组(降钙素原<0.5μg/L)。观察两组患者在1个月内的死亡情况、机械通气时间、APACHEⅡ评分,再根据患者在1个月内的死亡情况,分为死亡或放弃治疗组、存活组,比较两组的C反应蛋白和降钙素原水平。结果:高水平组患者在1个月内的死亡或放弃治疗率、机械通气时间、APACHEⅡ评分均高于低水平组(P<0.05);死亡或放弃治疗组患者的C反应蛋白、降钙素原水平均高于存活组(P<0.05)。结论:C反应蛋白和降钙素原检测在评估重症慢性阻塞性肺疾病患者病情的严重程度和预后中具有明显的临床应用价值。

Objective： To investigate the clinical value of C reactive protein and procalcitonin in patients with severe chronic obstructive pul- monary disease. Methods：269 cases of severe chronic obstructive pulmonary disease treated were divided into high level group （proealeitonin ≥0. 5μg/L） and low level group （ piocalcitonin 〈0.5μ g/L） according to the patients＇serum proealeitonin levels. The mortality of the patients within 1 month ,the mechanical ventilation time and APACHEII scoresin the two groups were observed. The patients were divided into the death or abandon treatment groupand the survival group according to the mortality within 1 month. The levels of C reactive protein and proealeitonin were compared between the two groups. Results： The rate of death or abandon treatment within 1 month, mechanical ventilation time and APACHEII scores of the patients in the high level group were significantly higher than those in the low level group （ P 〈0.05 ）. The level of C reactive protein in the death or abandon treatment group was significantly higher than that in the survival group （ P 〈 0.05 ）. The level of procalcitonin in the death or abandon treatment group was significantly higher than that in the survival group （ P 〈 0.05 ）. Conclusion： C reactive protein and procalcitonin have significant clinical value in assessing the severity and prognosis of patients with severe chronic obstructive pulmonary disease.