血清视黄醇结合蛋白、肌酐、尿素氮及胱抑素C对早期肾损伤的诊断价值

Diagnostic value of serum retinol-binding protein,creatinine,urea nitrogen and cystatin C in early renal injury

目的:探讨视黄醇结合蛋白(RBP)、肌酐(Cr)、尿素氮(BUN)及胱抑素C(Cys C)对早期肾损伤的诊断价值。方法:选取541例肾内科患者(依据尿蛋白定量分为A组341例、B组200例)及同期100名健康体检的人群(对照组),检测并对比分析各组的RBP、Cr、Cys C、BUN指标。结果:A、B两组患者的RBP、Cr、Cys C、BUN水平均高于对照组,且B组高于A组(P<0.05);B组患者的RBP、Cr、Cys C、BUN指标阳性率均高于A组(P<0.05);A、B两组患者的RBP、Cys C、BUN与Cr均有相关性。结论:RBP、Cr、Cys C、BUN指标在早期肾损伤的诊断中具有较高的应用价值,对于指导后续治疗具有重要意义。

Objective： To investigate the value of retinol - binding protein （ RBP）, creatinine （ Cr）, urea nitrogen （BUN） and cystatin C （CysC） in the diagnosis of early renal injury. Methods：541 patients with renal medicine were divided into two groups according to urinary protein quantification, 341 cases in group A, and 200 cases in group B. 100 normal people undergoing physical examination were enrolled as healthy group during the same period. The indexes of RBP, Cr, CysC and BUN in the three groups were detected and compared. Results： The parameters of RBP, Cr, CysC, and BUN in group A and group B were higher than those in the healthy group, group B higher than group A （ P 〈 0.05）. The positive rates of RBP, Cr, CysC and BUN in group B were higher than those in group A （ P 〈 0.05）. RBP, CysC and BUN in group A and group B were significantly correlated with Cr. Conclusion：The indexes of RBP, Cr, CysC and BUN are of high value in the diagnosis of early renal inju- ry, and have important significance in guiding the follow - up treatment.