人巨细胞病毒在不同疾病及不同标本的分布

The distribution of human cytomegalovirus in different diseases and specimens

目的调查人巨细胞病毒(HCMV)感染情况,分析HCMV感染在不同疾病及不同标本的分布情况,为临床有效控制HCMV感染提供依据。方法采用回顾性分析,查阅2013-2016年进行HCMV-DNA检测的病人住院病历,分析HCMV在不同疾病及不同标本的分布情况,并进行统计分析。结果 HCMV-DNA在不同标本中存在差异(χ~2=617.439,P<0.05),其中痰液标本阳性率最高,达39.65%(410/1 034);HCMV-DNA阳性患者主要集中分布在重症监护室(52.46%,662/1 262);年龄大于50岁患者更容易感染HCMV(χ~2=50.98,Ρ<0.05);HCMV阳性患者中以男性居多;HCMV阳性患者多见于呼吸道疾病(65.57%,562/857),其次为器官移植(22.98%,197/857);HCMV感染与EB病毒(EBV)感染不存在明显的相关性(r=0.800,P=0.200)。结论对年老及免疫功能低下的病人,加强HCMV感染筛查,联合不同标本进行检测,提高检出率,为临床治疗提供及时依据。

Objective To investigate infection status of human cytomegalovirus（HCMV） and analyze the distribution in different diseases and specimens,and provide the basis for further clinical effective control of HCMV infections. Methods The medical history records of all patients who underwent HCMV-testing were analyzed by SPSS 18.0. Result HCMV-DNA detection results in different specimens there is a difference（χ~2=617.439,P〈0.05）. The positive rate of sputum specimens was the highest（39.65%）（410/1 034）. HCMV-DNA positive patients were mainly concentrated in the intensive care unit（52.46%,662/1 262）;those older than 50 years old were more likely to be infected with HCMV（χ~2=50.98,P〈0.05）. HCMV positive patients were mostly male;HCMV positive patients were more common in respiratory diseases（65.57%,562/857）,followed by organ transplantation（22.98%,197/857）. Epstein-Barr virus（EBV）infection was not significantly correlated with HCMV infection（r=0.800,P=0.200）. Conclusion The HCMV-DNA detection for the elderly and immunocompromised patients was important. Combined with different specimens could improve the detection rate and provide timely evidence for clinical treatment.